PMID- 23212111
OWN - NLM
STAT- MEDLINE
DCOM- 20130923
LR  - 20211021
IS  - 1432-1238 (Electronic)
IS  - 0342-4642 (Linking)
VI  - 39
IP  - 2
DP  - 2013 Feb
TI  - A new formula for determining arterial oxygen saturation during venovenous 
      extracorporeal oxygenation.
PG  - 327-34
LID - 10.1007/s00134-012-2756-0 [doi]
AB  - PURPOSE: Venovenous extracorporeal membrane oxygenation (VV-ECMO) is used to 
      treat severe forms of acute respiratory distress syndrome (ARDS). VV-ECMO 
      management may be confusing due to the lack of information about the interplay 
      between the determinant parameters and their impact on oxygenation. We found a 
      relationship between arterial oxygen saturation (SaO(2)) and its relevant 
      parameters. The aim of this study was to assess the validity of this model. 
      METHODS: We report our experience in 17 patients under VV-ECMO for severe ARDS. 
      We compared, at two different levels of pump flow, SaO(2) and the oxygen 
      saturation measured in the pulmonary artery (SpaO(2)) with the predicted 
      saturation using the formula: SpaO(2) = (EF/CO)SmO(2) + (1 - EF/CO)SvO(2) + 
      10(-2)PmO(2), where PF is pump flow, R is recirculation, EF is effective flow [= 
      (1 - R)PF], SmO(2) is saturation of the oxygenator outgoing blood, CO is cardiac 
      output, SvO(2) is saturation of mixed venous blood, and PmO(2) is oxygen partial 
      pressure of the oxygenator outgoing blood. RESULTS: There was no significant 
      difference between predicted and measured SpaO(2): the mean predicted and 
      measured SpaO(2) values were 90.7 +/- 2.8 % and 90.4 +/- 2.7 % , respectively (p = 
      0.696, r = 0.966). Bland-Altman analysis showed good agreement between predicted 
      and measured SpaO(2). Predicted SpaO(2) and SaO(2) was well correlated (r = 
      0.80). CONCLUSIONS: We have presented an explicit relationship between SaO(2) and 
      its direct determinants during VV-ECMO. Good agreement was found with the 
      measured values of SaO(2), but the model remains to be fully validated before its 
      use in clinical practice.
FAU - Messai, Elmi
AU  - Messai E
AD  - Service de reanimation, Centre hospitalier de Cholet, 1 rue Marengo BP 507, 49325 
      Cholet, France. elmi.messai@ch-cholet.fr
FAU - Bouguerra, Abdesselam
AU  - Bouguerra A
FAU - Harmelin, Guy
AU  - Harmelin G
FAU - Di Lascio, Gabriella
AU  - Di Lascio G
FAU - Cianchi, Giovanni
AU  - Cianchi G
FAU - Bonacchi, Massimo
AU  - Bonacchi M
LA  - eng
PT  - Journal Article
PT  - Validation Study
DEP - 20121205
PL  - United States
TA  - Intensive Care Med
JT  - Intensive care medicine
JID - 7704851
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adult
MH  - Arteries
MH  - *Extracorporeal Membrane Oxygenation/methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Oximetry/*statistics & numerical data
MH  - Oxygen/*blood
MH  - Veins
EDAT- 2012/12/06 06:00
MHDA- 2013/09/24 06:00
CRDT- 2012/12/06 06:00
PHST- 2012/03/25 00:00 [received]
PHST- 2012/11/02 00:00 [accepted]
PHST- 2012/12/06 06:00 [entrez]
PHST- 2012/12/06 06:00 [pubmed]
PHST- 2013/09/24 06:00 [medline]
AID - 10.1007/s00134-012-2756-0 [doi]
PST - ppublish
SO  - Intensive Care Med. 2013 Feb;39(2):327-34. doi: 10.1007/s00134-012-2756-0. Epub 
      2012 Dec 5.