PMID- 23212274
OWN - NLM
STAT- MEDLINE
DCOM- 20131216
LR  - 20211021
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Print)
IS  - 1569-5794 (Linking)
VI  - 29
IP  - 4
DP  - 2013 Apr
TI  - Standard and feature tracking magnetic resonance evidence of myocardial 
      involvement in Churg-Strauss syndrome and granulomatosis with polyangiitis 
      (Wegener's) in patients with normal electrocardiograms and transthoracic 
      echocardiography.
PG  - 843-53
LID - 10.1007/s10554-012-0158-6 [doi]
AB  - The aim of the study was to evaluate the presence and spectrum of cardiac 
      abnormalities identified by cardiac magnetic resonance (CMR) in subjects in 
      clinical remission of Churg-Strauss syndrome (CSS) and granulomatosis with 
      polyangiitis (Wegener's) (WG) with normal ECG and transthoracic echocardiography 
      (TTE). Eleven (7 females, 4 males, mean age 42.4 +/- 9.6 years) CSS and 10 (4 
      females, 6 males, mean age 45.3 +/- 10.9 years) WG patients in clinical remission 
      with normal ECG and TTE underwent CMR. Segmental peak-systolic myocardial strain 
      (epsilonps) was measured using feature tracking cine-sequence based technique. Left 
      ventricular (LV) ejection fraction, end-diastolic volume and myocardial mass 
      indexes were 66.2 +/- 5.8 %, 66.1 +/- 6.6 ml/m(2), and 61.0 +/- 8.9 g/m(2), 
      respectively. No patient showed regional wall motion abnormalities and signs of 
      myocarditis. Nine CSS and 8 WG patients demonstrated decreased segmental 
      longitudinal, circumferential or radial epsilonps and myocardial late gadolinium 
      enhancement (LGE) (6 subendocardial, 10 midwall, 8 subepicardial) areas. In CSS 
      and WG subjects with LVLGE lesions the mean LVLGE extent was 2.0 +/- 1.6 % and 2.3 
      +/- 1.5 % (p = 0.65), respectively. Segmental epsilonps was decreased longitudinally 
      (-11.8 +/- 5.6 %) for subendocardial LGE, radially (13.7 +/- 8.7 %) for subepicardial 
      LGE, and circumferentially (-16.6 +/- 4.2 %), longitudinally (-13.2 +/- 5.5 %) and 
      radially (18.8 +/- 8.1 %) for midwall LGE, if compared to longitudinal (-22.7 +/- 5.1 
      %), circumferential (-23.6 +/- 5.6 %) and radial (34.2 +/- 15.7 %) epsilonps in controls 
      (11 females, 10 males, mean age 43.9 +/- 10.5 years) (all p < 0.01). Despite 
      clinical remission, normal ECG and TTE, most CSS and WG patients demonstrate 
      decreased segmental epsilonps and non-ischemic LGE lesions without signs of 
      myocarditis.
FAU - Miszalski-Jamka, Tomasz
AU  - Miszalski-Jamka T
AD  - Center for Diagnosis, Prevention and Telemedicine, John Paul II Hospital, ul. 
      Pradnicka 80, 31-202 Krakow, Poland. miszalt@mp.pl
FAU - Szczeklik, Wojciech
AU  - Szczeklik W
FAU - Sokolowska, Barbara
AU  - Sokolowska B
FAU - Karwat, Krzysztof
AU  - Karwat K
FAU - Belzak, Katarzyna
AU  - Belzak K
FAU - Mazur, Wojciech
AU  - Mazur W
FAU - Kereiakes, Dean J
AU  - Kereiakes DJ
FAU - Musial, Jacek
AU  - Musial J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121205
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
SB  - IM
MH  - Adult
MH  - Cardiomyopathies/*diagnosis/diagnostic imaging/etiology/pathology/physiopathology
MH  - Chi-Square Distribution
MH  - Churg-Strauss Syndrome/*complications/diagnosis
MH  - *Echocardiography
MH  - *Electrocardiography
MH  - Female
MH  - Granulomatosis with Polyangiitis/*complications/diagnosis
MH  - Humans
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Multimodal Imaging
MH  - Myocardium/*pathology
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Prospective Studies
MH  - Ventricular Function, Left
PMC - PMC3644401
EDAT- 2012/12/06 06:00
MHDA- 2013/12/18 06:00
PMCR- 2012/12/05
CRDT- 2012/12/06 06:00
PHST- 2012/08/01 00:00 [received]
PHST- 2012/11/14 00:00 [accepted]
PHST- 2012/12/06 06:00 [entrez]
PHST- 2012/12/06 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
PHST- 2012/12/05 00:00 [pmc-release]
AID - 158 [pii]
AID - 10.1007/s10554-012-0158-6 [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2013 Apr;29(4):843-53. doi: 10.1007/s10554-012-0158-6. 
      Epub 2012 Dec 5.