PMID- 23212455
OWN - NLM
STAT- MEDLINE
DCOM- 20131029
LR  - 20221207
IS  - 1740-634X (Electronic)
IS  - 0893-133X (Print)
IS  - 0893-133X (Linking)
VI  - 38
IP  - 4
DP  - 2013 Mar
TI  - In vivo effects of abused 'bath salt' constituent 3,4-methylenedioxypyrovalerone 
      (MDPV) in mice: drug discrimination, thermoregulation, and locomotor activity.
PG  - 563-73
LID - 10.1038/npp.2012.233 [doi]
AB  - In recent years, synthetic analogues of naturally occurring cathinone have 
      emerged as psychostimulant-like drugs of abuse in commercial 'bath salt' 
      preparations. 3,4-Methylenedioxypyrovalerone (MDPV) is a common constituent of 
      these illicit products, and its structural similarities to the more well-known 
      drugs of abuse 3,4-methylenedioxymethamphetamine (MDMA), and methamphetamine 
      (METH) suggest that it may have similar in vivo effects to these substances. In 
      these studies, adult male NIH Swiss mice were trained to discriminate 0.3 mg/kg 
      MDPV from saline, and the interoceptive effects of a range of substitution doses 
      of MDPV, MDMA, and METH were then assessed. In separate groups of mice, 
      surgically implanted radiotelemetry probes simultaneously monitored 
      thermoregulatory and locomotor responses to various doses of MDPV and MDMA, as a 
      function of ambient temperature. We found that mice reliably discriminated the 
      MDPV training dose from saline and that cumulative doses of MDPV, MDMA, and METH 
      fully substituted for the MDPV training stimulus. All three drugs had similar 
      ED(50) values in this procedure. Stimulation of motor activity was observed 
      following administration of a wide range of MDPV doses (1-30 mg/kg), and the warm 
      ambient temperature potentiated motor activity and elicited profound stereotypy 
      and self-injurious behavior at 30 mg/kg. In contrast, MDPV-induced hyperthermic 
      effects were observed in only the warm ambient environment. This pattern of 
      effects is in sharp contrast to MDMA, where ambient temperature interacts with 
      thermoregulation, but not locomotor activity. These studies suggest that although 
      the interoceptive effects of MDPV are similar to those of MDMA and METH, direct 
      effects on thermoregulatory processes and locomotor activity are likely mediated 
      by different mechanisms than those of MDMA.
FAU - Fantegrossi, William E
AU  - Fantegrossi WE
AD  - Department of Pharmacology and Toxicology, College of Medicine, University of 
      Arkansas for Medical Sciences, Little Rock, AR 72205, USA. WEFantegrossi@uams.edu
FAU - Gannon, Brenda M
AU  - Gannon BM
FAU - Zimmerman, Sarah M
AU  - Zimmerman SM
FAU - Rice, Kenner C
AU  - Rice KC
LA  - eng
GR  - P20 RR020146/RR/NCRR NIH HHS/United States
GR  - UL1 RR029884/RR/NCRR NIH HHS/United States
GR  - RR029884/RR/NCRR NIH HHS/United States
GR  - RR020146/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20121108
PL  - England
TA  - Neuropsychopharmacology
JT  - Neuropsychopharmacology : official publication of the American College of 
      Neuropsychopharmacology
JID - 8904907
RN  - 0 (Benzodioxoles)
RN  - 0 (Designer Drugs)
RN  - 0 (Pyrrolidines)
RN  - 0 (Synthetic Cathinone)
SB  - IM
MH  - Animals
MH  - Benzodioxoles/*pharmacology
MH  - Body Temperature Regulation/*drug effects/physiology
MH  - Conditioning, Operant/drug effects/physiology
MH  - Designer Drugs/*pharmacology
MH  - Discrimination, Psychological/*drug effects/physiology
MH  - Male
MH  - Mice
MH  - Motor Activity/*drug effects/physiology
MH  - Pyrrolidines/*pharmacology
MH  - Synthetic Cathinone
PMC - PMC3572465
EDAT- 2012/12/06 06:00
MHDA- 2013/10/30 06:00
PMCR- 2014/03/01
CRDT- 2012/12/06 06:00
PHST- 2012/12/06 06:00 [entrez]
PHST- 2012/12/06 06:00 [pubmed]
PHST- 2013/10/30 06:00 [medline]
PHST- 2014/03/01 00:00 [pmc-release]
AID - npp2012233 [pii]
AID - 10.1038/npp.2012.233 [doi]
PST - ppublish
SO  - Neuropsychopharmacology. 2013 Mar;38(4):563-73. doi: 10.1038/npp.2012.233. Epub 
      2012 Nov 8.