PMID- 23212465
OWN - NLM
STAT- MEDLINE
DCOM- 20131119
LR  - 20211021
IS  - 1865-3774 (Electronic)
IS  - 0925-5710 (Linking)
VI  - 97
IP  - 1
DP  - 2013 Jan
TI  - 18F-FDG uptake in primary gastric malignant lymphoma correlates with glucose 
      transporter 1 expression and histologic malignant potential.
PG  - 43-9
LID - 10.1007/s12185-012-1225-4 [doi]
AB  - Positron emission tomography (PET) is used for staging and response evaluation in 
      primary gastric lymphoma (PGL). However, the implications of 
      [(18)F]-2-fluoro-2-deoxy-D-glucose ((18)F-FDG) uptake in PGL at first diagnosis 
      have not been reported. The relationship between (18)F-FDG uptake and the 
      expression of facilitative glucose transporters (GLUTs), hexokinase II (HK II), 
      and Ki67, as well as malignant potential in PGL, was assessed in this study. We 
      analyzed 23 patients with PGL [nine with diffuse large B-cell lymphoma (DLBCL); 
      seven with high-grade mucosa-associated lymphoid tissue (MALT) lymphoma; and 
      seven with low-grade MALT lymphoma]. The expression levels of GLUT1, GLUT3, HK 
      II, and Ki67 were evaluated according to the percentage of positive area 
      determined by immunohistochemistry. Standardized uptake values correlated 
      significantly with pathological malignant potentials (low-grade/high-grade MALT 
      lymphoma and DLBCL: p = 0.001-0.002), Ki67 (p < 0.001), and GLUT1 expression 
      (p = 0.02). We determined that (18)F-FDG uptake is related to GLUT1 expression 
      and tumor histological grade as well as Ki67 in PGL.
FAU - Watanabe, Yuko
AU  - Watanabe Y
AD  - Department of Radiology, Kurume University School of Medicine, 67 Asahi-Machi, 
      Kurume, Fukuoka, Japan.
FAU - Suefuji, Hiroaki
AU  - Suefuji H
FAU - Hirose, Yasumitsu
AU  - Hirose Y
FAU - Kaida, Hayato
AU  - Kaida H
FAU - Suzuki, Gen
AU  - Suzuki G
FAU - Uozumi, Jun
AU  - Uozumi J
FAU - Ogo, Etsuyo
AU  - Ogo E
FAU - Miura, Mayumi
AU  - Miura M
FAU - Takasu, Konomi
AU  - Takasu K
FAU - Miyazaki, Kanoko
AU  - Miyazaki K
FAU - Nakahara, Keita
AU  - Nakahara K
FAU - Ishibashi, Masatoshi
AU  - Ishibashi M
FAU - Okamura, Takashi
AU  - Okamura T
FAU - Ohshima, Koichi
AU  - Ohshima K
FAU - Hayabuchi, Naofumi
AU  - Hayabuchi N
LA  - eng
PT  - Journal Article
DEP - 20121202
PL  - Japan
TA  - Int J Hematol
JT  - International journal of hematology
JID - 9111627
RN  - 0 (Glucose Transporter Type 1)
RN  - 0 (Glucose Transporter Type 3)
RN  - 0 (Ki-67 Antigen)
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
RN  - EC 2.7.1.1 (Hexokinase)
RN  - Familial primary gastric lymphoma
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Fluorodeoxyglucose F18/*metabolism
MH  - Gastroscopy
MH  - Glucose Transporter Type 1/*metabolism
MH  - Glucose Transporter Type 3/metabolism
MH  - Hexokinase/metabolism
MH  - Humans
MH  - Ki-67 Antigen/metabolism
MH  - Lymphoma, Non-Hodgkin/*diagnosis/*metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - *Multimodal Imaging
MH  - Neoplasm Grading
MH  - Neoplasm Staging
MH  - *Positron-Emission Tomography
MH  - Stomach Neoplasms/*diagnosis/*metabolism/pathology
MH  - *Tomography, X-Ray Computed
EDAT- 2012/12/06 06:00
MHDA- 2013/11/20 06:00
CRDT- 2012/12/06 06:00
PHST- 2012/09/06 00:00 [received]
PHST- 2012/11/13 00:00 [accepted]
PHST- 2012/11/07 00:00 [revised]
PHST- 2012/12/06 06:00 [entrez]
PHST- 2012/12/06 06:00 [pubmed]
PHST- 2013/11/20 06:00 [medline]
AID - 10.1007/s12185-012-1225-4 [doi]
PST - ppublish
SO  - Int J Hematol. 2013 Jan;97(1):43-9. doi: 10.1007/s12185-012-1225-4. Epub 2012 Dec 
      2.