PMID- 23212475
OWN - NLM
STAT- MEDLINE
DCOM- 20130219
LR  - 20211021
IS  - 1471-0080 (Electronic)
IS  - 1471-0072 (Linking)
VI  - 14
IP  - 1
DP  - 2013 Jan
TI  - New insights into the regulation and cellular functions of the ARP2/3 complex.
PG  - 7-12
LID - 10.1038/nrm3492 [doi]
AB  - The actin-related protein 2/3 (ARP2/3) complex nucleates branched actin filament 
      networks, but requires nucleation promoting factors (NPFs) to stimulate this 
      activity. NPFs include proteins such as Wiskott-Aldrich syndrome protein (WASP), 
      neural WASP (NWASP), WASP family verprolin-homologous protein (WAVE; also known 
      as SCAR) and the recently identified WASP and SCAR homologue (WASH) complex. The 
      mechanisms underlying NPF-dependent regulation and the cellular functions of 
      ARP2/3 are being unravelled using new chemical and genetic approaches. Of 
      particular interest is the role of the ARP2/3 complex in vesicular trafficking 
      and directional cell motility.
FAU - Rotty, Jeremy D
AU  - Rotty JD
AD  - UNC Lineberger Comprehensive Cancer Center, Department of Cell Biology and 
      Physiology, University of North Carolina School of Medicine, Chapel Hill, North 
      Carolina 27599, USA.
FAU - Wu, Congying
AU  - Wu C
FAU - Bear, James E
AU  - Bear JE
LA  - eng
GR  - GM083035/GM/NIGMS NIH HHS/United States
GR  - Howard Hughes Medical Institute/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20121205
PL  - England
TA  - Nat Rev Mol Cell Biol
JT  - Nature reviews. Molecular cell biology
JID - 100962782
RN  - 0 (Actin-Related Protein 2-3 Complex)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (Microfilament Proteins)
RN  - 0 (WASF1 protein, human)
RN  - 0 (WASH protein, human)
RN  - 0 (Wiskott-Aldrich Syndrome Protein)
RN  - 0 (Wiskott-Aldrich Syndrome Protein Family)
RN  - 0 (Wiskott-Aldrich Syndrome Protein, Neuronal)
SB  - IM
MH  - Actin-Related Protein 2-3 Complex/*metabolism
MH  - Cell Movement
MH  - Cytoskeletal Proteins/metabolism
MH  - Humans
MH  - Microfilament Proteins/*metabolism
MH  - Protein Conformation
MH  - Protein Transport
MH  - Wiskott-Aldrich Syndrome Protein/*metabolism
MH  - Wiskott-Aldrich Syndrome Protein Family/*metabolism
MH  - Wiskott-Aldrich Syndrome Protein, Neuronal/*metabolism
EDAT- 2012/12/06 06:00
MHDA- 2013/02/21 06:00
CRDT- 2012/12/06 06:00
PHST- 2012/12/06 06:00 [entrez]
PHST- 2012/12/06 06:00 [pubmed]
PHST- 2013/02/21 06:00 [medline]
AID - nrm3492 [pii]
AID - 10.1038/nrm3492 [doi]
PST - ppublish
SO  - Nat Rev Mol Cell Biol. 2013 Jan;14(1):7-12. doi: 10.1038/nrm3492. Epub 2012 Dec 
      5.