PMID- 23213535
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121206
LR  - 20211021
IS  - 2090-3006 (Electronic)
IS  - 2090-2999 (Print)
IS  - 2090-3006 (Linking)
VI  - 2012
DP  - 2012
TI  - Human leukocyte antigen profiles of latin american populations: differential 
      admixture and its potential impact on hematopoietic stem cell transplantation.
PG  - 136087
LID - 10.1155/2012/136087 [doi]
LID - 136087
AB  - The outcome of hematopoietic stem cell transplantation (HSCT) is shaped by both 
      clinical and genetic factors that determine its success. Genetic factors 
      including human leukocyte antigen (HLA) and non-HLA genetic variants are believed 
      to influence the risk of potentially fatal complications after the transplant. 
      Moreover, ethnicity has been proposed as a factor modifying the risk of 
      graft-versus-host disease. The populations of Latin America are a complex array 
      of different admixture processes with varying degrees of ancestral population 
      proportions that came in different migration waves. This complexity makes the 
      study of genetic risks in this region complicated unless the extent of this 
      variation is thoroughly characterized. In this study we compared the HLA-A and 
      HLA-B allele group profiles for 31 Latin American populations and 61 ancestral 
      populations from Iberia, Italy, Sub-Saharan Africa, and America. Results from 
      population genetics comparisons show a wide variation in the HLA profiles from 
      the Latin American populations that correlate with different admixture 
      proportions. Populations in Latin America seem to be organized in at least three 
      groups with (1) strong Amerindian admixture, (2) strong Caucasian component, and 
      (3) a Caucasian-African gradient. These results imply that genetic risk 
      assessment for HSCT in Latin America has to be adapted for different population 
      subgroups rather than as a pan-Hispanic/Latino analysis.
FAU - Arrieta-Bolanos, Esteban
AU  - Arrieta-Bolanos E
AD  - Clinical Research Group, The Anthony Nolan Research Institute, Royal Free & 
      University College Medical School, London NW3 2QG, UK ; University College London 
      Cancer Institute, London WC1E 6DD, UK ; Centro de Investigaciones en Hematologia 
      y Trastornos Afines (CIHATA), Universidad de Costa Rica, 11501-2060 San Jose, 
      Costa Rica.
FAU - Madrigal, J Alejandro
AU  - Madrigal JA
FAU - Shaw, Bronwen E
AU  - Shaw BE
LA  - eng
PT  - Journal Article
DEP - 20121118
PL  - Egypt
TA  - Bone Marrow Res
JT  - Bone marrow research
JID - 101566202
PMC - PMC3506882
EDAT- 2012/12/06 06:00
MHDA- 2012/12/06 06:01
PMCR- 2012/11/18
CRDT- 2012/12/06 06:00
PHST- 2012/08/06 00:00 [received]
PHST- 2012/10/12 00:00 [accepted]
PHST- 2012/12/06 06:00 [entrez]
PHST- 2012/12/06 06:00 [pubmed]
PHST- 2012/12/06 06:01 [medline]
PHST- 2012/11/18 00:00 [pmc-release]
AID - 10.1155/2012/136087 [doi]
PST - ppublish
SO  - Bone Marrow Res. 2012;2012:136087. doi: 10.1155/2012/136087. Epub 2012 Nov 18.