PMID- 23215636
OWN - NLM
STAT- MEDLINE
DCOM- 20130801
LR  - 20130220
IS  - 1557-8577 (Electronic)
IS  - 1549-1684 (Linking)
VI  - 16
IP  - 1
DP  - 2013 Feb
TI  - Brain-derived neurotrophic factor gene variants and Alzheimer disease: an 
      association study in an Alzheimer disease Italian population.
PG  - 57-66
LID - 10.1089/rej.2012.1381 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) promotes neuronal survival during 
      development and protects neurons from insults of various kinds. Changes in 
      production of BDNF have been reported in differing neurodegenerative pathologies 
      and, in particular, in Alzheimer disease (AD). We studied 200 AD patients and 408 
      healthy controls for BDNF Val66Met(G196A) polymorphism, 200AD and 384 healthy 
      controls for BDNF 270 C/T polymorphism, and 200AD and 393 healthy controls for 
      BDNF 11757 G/C polymorphism by restriction fragment length polymorphism (RFLP) 
      and real-time PCR. Our results indicated that the 11757 G/C BDNF polymorphism was 
      significantly associated with AD. A statistically significant increase of GG 
      genotype frequency in AD versus healthy subjects (p=0.0331) was observed, whereas 
      the CG genotype demonstrates a statistically significant decrease of frequency in 
      AD patients versus controls (p=0.0194). We focused our attention on haplotype 
      reconstruction: A statistically significant decrease of the TAC haplotype 
      frequency in AD patients versus healthy controls group (p=0.005) and a 
      statistically significant increase of the CAC haplotype frequency in patients 
      versus control (p=0.019) was demonstrated. We then studied the haplotype 
      frequencies dividing patients according to gender. A statistically significant 
      increase of the CAC haplotype in the male AD group compared with male healthy 
      controls (p=0.041) was found, whereas a statistically significant decrease of TAC 
      haplotype frequency in AD females versus healthy females (p=0.005) and a 
      statistically significant increase of CAC haplotype frequency in female patients 
      versus healthy females (p=0.019) was noticed. We propose that these haplotypes 
      could be a further effective marker for AD.
FAU - Boiocchi, Chiara
AU  - Boiocchi C
AD  - IRCCS National Neurological Institute C. Mondino, Pavia, Italy. 
      chiara.boiocchi@unipv.it
FAU - Maggioli, Elisa
AU  - Maggioli E
FAU - Zorzetto, Michele
AU  - Zorzetto M
FAU - Sinforiani, Elena
AU  - Sinforiani E
FAU - Cereda, Cristina
AU  - Cereda C
FAU - Ricevuti, Giovanni
AU  - Ricevuti G
FAU - Cuccia, Mariaclara
AU  - Cuccia M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Rejuvenation Res
JT  - Rejuvenation research
JID - 101213381
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (DNA Primers)
SB  - IM
MH  - Alzheimer Disease/*genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Case-Control Studies
MH  - DNA Primers
MH  - Female
MH  - *Genetics, Population
MH  - Haplotypes
MH  - Humans
MH  - Italy
MH  - Male
MH  - Polymorphism, Restriction Fragment Length
MH  - Polymorphism, Single Nucleotide
MH  - Real-Time Polymerase Chain Reaction
EDAT- 2012/12/12 06:00
MHDA- 2013/08/02 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/08/02 06:00 [medline]
AID - 10.1089/rej.2012.1381 [doi]
PST - ppublish
SO  - Rejuvenation Res. 2013 Feb;16(1):57-66. doi: 10.1089/rej.2012.1381.