PMID- 23215852
OWN - NLM
STAT- MEDLINE
DCOM- 20130703
LR  - 20130121
IS  - 2212-3334 (Electronic)
IS  - 1872-2148 (Linking)
VI  - 7
IP  - 1
DP  - 2013 Jan
TI  - Cancer therapy based on a mechanism of action for controlling the immune system 
      and the resulting patent portfolio.
PG  - 1-10
AB  - Despite decades of research, current cancer therapies extend survival but often 
      do not actually cure the disease. Immune cell based therapy is described here 
      that can eliminate tumor cells without the toxicity associated with chemotherapy 
      or allogeneic bone marrow transplant (BMT). Allogeneic BMT has beneficial graft 
      vs. tumor (GVT) effects but accompanied by the undesirable graft vs. host disease 
      (GVHD). The mechanism described here relates to generating the Mirror Effect 
      that elicits a host vs. tumor (HVT) effect along with a non-toxic host vs. graft 
      (HVG) response. The HVT effect generated by inducing the Mirror Effect in a host 
      is effective in cancer therapy, as well as other diseases. The patent strategy, 
      employed for successful patent prosecution related to the elucidation of the 
      Mirror Effect, is also discussed.
FAU - Goswitz, Visala C
AU  - Goswitz VC
AD  - Westman, Champlin and Kelly, P.A. 900 Second Avenue South, Minneapolis, MN 55402 
      USA.
FAU - Sawicki, Z Peter
AU  - Sawicki ZP
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United Arab Emirates
TA  - Recent Pat Endocr Metab Immune Drug Discov
JT  - Recent patents on endocrine, metabolic & immune drug discovery
JID - 101299743
SB  - IM
MH  - Animals
MH  - Bone Marrow Transplantation/adverse effects/*immunology
MH  - Graft vs Host Disease/etiology/prevention & control
MH  - Graft vs Tumor Effect/immunology
MH  - Humans
MH  - Immunotherapy/adverse effects/*methods
MH  - Neoplasms/immunology/*therapy
MH  - Patents as Topic
MH  - Transplantation, Homologous
EDAT- 2012/12/12 06:00
MHDA- 2013/07/05 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/11/14 00:00 [received]
PHST- 2012/11/30 00:00 [revised]
PHST- 2012/11/28 00:00 [accepted]
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/07/05 06:00 [medline]
AID - EMI-EPUB-20121203-1 [pii]
PST - ppublish
SO  - Recent Pat Endocr Metab Immune Drug Discov. 2013 Jan;7(1):1-10.