PMID- 23216110
OWN - NLM
STAT- MEDLINE
DCOM- 20130530
LR  - 20131121
IS  - 1557-7600 (Electronic)
IS  - 1096-620X (Linking)
VI  - 15
IP  - 12
DP  - 2012 Dec
TI  - Cordyceps militaris extract attenuates D-galactose-induced memory impairment in 
      mice.
PG  - 1057-63
LID - 10.1089/jmf.2011.2105 [doi]
AB  - Memory impairment is one of main clinical symptoms of brain senescence. To 
      address the effects of Cordyceps militaris Link extract (CE) on memory 
      impairment, a D-galactose (D-Gal)-induced aging mouse model was employed. Mice 
      injected with D-Gal showed a significant learning and memory impairment that was 
      rescued by CE treatment. The mechanism was further investigated by analyzing the 
      protein level and activity of oxidant and antioxidant molecules, including 
      malondialdehyde (MDA), monoamine oxidase (MAO), total super-oxide dismutase 
      (T-SOD), total antioxidant capacity (T-AOC), glutathione (GSH), and glutathione 
      peroxidase (GSH-px), which played critical roles in the development of brain 
      senescence. The results showed that CE treatment resulted in a significant 
      decrease in the oxidative activity of MAO and the level of MDA, and significantly 
      increased the antioxidant activities of T-SOD and T-AOC in the cerebral cortices. 
      Moreover, the level of GSH and the activity of antioxidant enzymes GSH-px in 
      serum were significantly upregulated after CE treatment. Taken together, our 
      results suggest that Cordyceps militaris extract could ameliorate experimental 
      memory impairment in mice with D-Gal-induced aging through its potent antioxidant 
      activities.
FAU - Li, Zaixin
AU  - Li Z
AD  - School of Chemistry and Pharmaceutical Engineering, University of Sichuan Science 
      and Engineering, Zigong, China. lizaixin@sina.com
FAU - Zhang, Zhi
AU  - Zhang Z
FAU - Zhang, Jinshan
AU  - Zhang J
FAU - Jia, Jing
AU  - Jia J
FAU - Ding, Jie
AU  - Ding J
FAU - Luo, Rongzhen
AU  - Luo R
FAU - Liu, Zhangqin
AU  - Liu Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121210
PL  - United States
TA  - J Med Food
JT  - Journal of medicinal food
JID - 9812512
RN  - 0 (Antioxidants)
RN  - 0 (Neuroprotective Agents)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 1.4.3.4 (Monoamine Oxidase)
RN  - GAN16C9B8O (Glutathione)
RN  - X2RN3Q8DNE (Galactose)
SB  - IM
MH  - Aging/drug effects
MH  - Animals
MH  - Antioxidants/analysis
MH  - Cerebral Cortex/drug effects/metabolism
MH  - Cordyceps/*chemistry
MH  - Disease Models, Animal
MH  - Female
MH  - Galactose/*adverse effects
MH  - Glutathione/analysis
MH  - Glutathione Peroxidase/analysis
MH  - Malondialdehyde/analysis
MH  - Maze Learning/drug effects
MH  - Memory Disorders/chemically induced/*drug therapy
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Monoamine Oxidase/analysis
MH  - Neuroprotective Agents/*pharmacology
MH  - Oxidative Stress/drug effects
MH  - Superoxide Dismutase/analysis
MH  - Up-Regulation
EDAT- 2012/12/12 06:00
MHDA- 2013/06/01 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/06/01 06:00 [medline]
AID - 10.1089/jmf.2011.2105 [doi]
PST - ppublish
SO  - J Med Food. 2012 Dec;15(12):1057-63. doi: 10.1089/jmf.2011.2105. Epub 2012 Dec 
      10.