PMID- 23216287
OWN - NLM
STAT- MEDLINE
DCOM- 20131118
LR  - 20221207
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 81
IP  - 1
DP  - 2013 Jan
TI  - HLA antigen, allele and haplotype frequencies and their use in virtual panel 
      reactive antigen calculations in the Finnish population.
PG  - 35-43
LID - 10.1111/tan.12036 [doi]
AB  - The human leukocyte antigen (HLA) antigen, allele and haplotype frequencies of 
      the Finnish population are quite unique because of a rather restricted and 
      homogeneous gene pool. This has a strong influence on finding suitable donors for 
      transplant patients; hence knowledge about the HLA frequencies of the patient 
      population is essential. Here we report the HLA antigen frequencies for a large 
      population sample and show high resolution HLA allele frequencies for 11 loci, 
      including the rarely typed DPA1 and DQA1 loci. Furthermore, the most common 
      Finnish high resolution haplotypes are presented for five HLA loci. The study 
      shows that there are fewer HLA haplotypes in the Finnish population compared with 
      mixed populations, and the common Finnish HLA haplotypes are more frequent. Using 
      HLA antibody identification and panel reactive antibody calculations we show that 
      a virtual population-specific panel, combined with single antigen testing, gives 
      a more accurate and reliable estimate of the reactivity of the recipient serum 
      against potential solid organ donors within the Finnish population. The results 
      can be directly used to improve donor search for patients waiting for stem cell 
      transplantation and to allocate highly immunised patients accurately to 
      acceptable mismatch programs.
CI  - (c) 2012 John Wiley & Sons A/S.
FAU - Haimila, K
AU  - Haimila K
AD  - Clinical Laboratory, Finnish Red Cross Blood Service, Helsinki, Finland. 
      katri.haimila@bts.redcross.fi
FAU - Perasaari, J
AU  - Perasaari J
FAU - Linjama, T
AU  - Linjama T
FAU - Koskela, S
AU  - Koskela S
FAU - Saarinenl, T
AU  - Saarinenl T
FAU - Lauronen, J
AU  - Lauronen J
FAU - Auvinen, M-K
AU  - Auvinen MK
FAU - Jaatinen, T
AU  - Jaatinen T
LA  - eng
PT  - Journal Article
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
SB  - IM
MH  - *Alleles
MH  - Finland
MH  - *Gene Frequency
MH  - HLA Antigens/*genetics
MH  - *Haplotypes
MH  - Humans
MH  - Tissue Donors
MH  - White People
EDAT- 2012/12/12 06:00
MHDA- 2013/11/19 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/03/02 00:00 [received]
PHST- 2012/09/10 00:00 [revised]
PHST- 2012/10/25 00:00 [accepted]
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/11/19 06:00 [medline]
AID - 10.1111/tan.12036 [doi]
PST - ppublish
SO  - Tissue Antigens. 2013 Jan;81(1):35-43. doi: 10.1111/tan.12036.