PMID- 23216612
OWN - NLM
STAT- MEDLINE
DCOM- 20130517
LR  - 20201215
IS  - 1040-8401 (Print)
IS  - 1040-8401 (Linking)
VI  - 32
IP  - 2
DP  - 2012
TI  - Crosstalk between T lymphocytes and dendritic cells.
PG  - 139-55
AB  - Dendritic cells (DCs) are professional antigen-presenting cells (APCs) with the 
      unique property of inducing priming and differentiation of naive CD4+ and CD8+ T 
      cells into helper and cytotoxic effectors. Their efficiency is due to their 
      unique ability to process antigen, express costimulatory molecules, secrete 
      cytokines, and migrate to tissues or lymphoid organs to prime T cells. DCs also 
      play an important role in T-cell peripheral tolerance. There is ample evidence 
      that the DC ability to present antigens is regulated by CD4+ helper T cells. 
      Indeed, interactions between surface receptors and ligands expressed respectively 
      by T cells and DCs, as well as T-cell-derived cytokines modify DC functions. This 
      T-cell-induced modification of DCs has been called "education" or "licensing." 
      This intimate crosstalk between DCs and T lymphocytes is key in establishing 
      appropriate adaptive immune responses. It requires cognate interactions between T 
      lymphocytes and DCs, which are organized in time and space by structures called 
      immunological synapses. Here we discuss the particular aspects of immunological 
      synapses formed between T cells and DCs and the role these organized interactions 
      have in T-cell-DC crosstalk.
FAU - Hivroz, Claire
AU  - Hivroz C
AD  - Institut Curie, Centre de Recherche, Pavilion Pasteur, 26 Rue d'ULM, Paris, 
      F-75248, France. hivroz@curie.fr
FAU - Chemin, Karine
AU  - Chemin K
FAU - Tourret, Marie
AU  - Tourret M
FAU - Bohineust, Armelle
AU  - Bohineust A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Crit Rev Immunol
JT  - Critical reviews in immunology
JID - 8914819
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - Antigen Presentation
MH  - CD4-Positive T-Lymphocytes/*immunology
MH  - *Cell Communication
MH  - Cytokines/immunology
MH  - Cytoskeleton/*immunology
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Immunological Synapses/*immunology
MH  - Lymphocyte Activation
MH  - Peripheral Tolerance
MH  - Receptor Cross-Talk/immunology
EDAT- 2012/12/12 06:00
MHDA- 2013/05/18 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/05/18 06:00 [medline]
AID - 3bfedc2e7294b37d,2bf4a1c53dab5ad3 [pii]
AID - 10.1615/critrevimmunol.v32.i2.30 [doi]
PST - ppublish
SO  - Crit Rev Immunol. 2012;32(2):139-55. doi: 10.1615/critrevimmunol.v32.i2.30.