PMID- 23217257
OWN - NLM
STAT- MEDLINE
DCOM- 20130522
LR  - 20211021
IS  - 1932-7420 (Electronic)
IS  - 1550-4131 (Print)
IS  - 1550-4131 (Linking)
VI  - 16
IP  - 6
DP  - 2012 Dec 5
TI  - Chronic caloric restriction preserves mitochondrial function in senescence 
      without increasing mitochondrial biogenesis.
PG  - 777-88
LID - S1550-4131(12)00456-1 [pii]
LID - 10.1016/j.cmet.2012.11.003 [doi]
AB  - Caloric restriction (CR) mitigates many detrimental effects of aging and prolongs 
      life span. CR has been suggested to increase mitochondrial biogenesis, thereby 
      attenuating age-related declines in mitochondrial function, a concept that is 
      challenged by recent studies. Here we show that lifelong CR in mice prevents 
      age-related loss of mitochondrial oxidative capacity and efficiency, measured in 
      isolated mitochondria and permeabilized muscle fibers. We find that these 
      beneficial effects of CR occur without increasing mitochondrial abundance. 
      Whole-genome expression profiling and large-scale proteomic surveys revealed 
      expression patterns inconsistent with increased mitochondrial biogenesis, which 
      is further supported by lower mitochondrial protein synthesis with CR. We find 
      that CR decreases oxidant emission, increases antioxidant scavenging, and 
      minimizes oxidative damage to DNA and protein. These results demonstrate that CR 
      preserves mitochondrial function by protecting the integrity and function of 
      existing cellular components rather than by increasing mitochondrial biogenesis.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Lanza, Ian R
AU  - Lanza IR
AD  - Division of Endocrinology and Metabolism, Mayo Clinic College of Medicine, 200 
      First Street SW, Rochester, MN 55905, USA.
FAU - Zabielski, Piotrek
AU  - Zabielski P
FAU - Klaus, Katherine A
AU  - Klaus KA
FAU - Morse, Dawn M
AU  - Morse DM
FAU - Heppelmann, Carrie J
AU  - Heppelmann CJ
FAU - Bergen, H Robert 3rd
AU  - Bergen HR 3rd
FAU - Dasari, Surendra
AU  - Dasari S
FAU - Walrand, Stephane
AU  - Walrand S
FAU - Short, Kevin R
AU  - Short KR
FAU - Johnson, Matthew L
AU  - Johnson ML
FAU - Robinson, Matthew M
AU  - Robinson MM
FAU - Schimke, Jill M
AU  - Schimke JM
FAU - Jakaitis, Daniel R
AU  - Jakaitis DR
FAU - Asmann, Yan W
AU  - Asmann YW
FAU - Sun, Zhifu
AU  - Sun Z
FAU - Nair, K Sreekumaran
AU  - Nair KS
LA  - eng
SI  - GEO/GSE36285
GR  - KL2TR000136-07/TR/NCATS NIH HHS/United States
GR  - T32 DK007198/DK/NIDDK NIH HHS/United States
GR  - KL2 TR000136/TR/NCATS NIH HHS/United States
GR  - R01-AG09531/AG/NIA NIH HHS/United States
GR  - R01 AG009531/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell Metab
JT  - Cell metabolism
JID - 101233170
RN  - 0 (DNA, Mitochondrial)
RN  - 0 (Mitochondrial Proteins)
RN  - 0 (Muscle Proteins)
RN  - EC 1.3.5.1 (Electron Transport Complex II)
RN  - EC 7.1.1.2 (Electron Transport Complex I)
SB  - IM
MH  - Aging
MH  - Animals
MH  - *Caloric Restriction
MH  - DNA, Mitochondrial/metabolism
MH  - Down-Regulation
MH  - Electron Transport Complex I/metabolism
MH  - Electron Transport Complex II/metabolism
MH  - Gene Expression Profiling
MH  - Mice
MH  - Mitochondria/genetics/*metabolism
MH  - Mitochondrial Proteins/genetics/metabolism
MH  - Mitochondrial Turnover/*physiology
MH  - Muscle Proteins/metabolism
MH  - Muscle, Skeletal/metabolism
MH  - Oxidative Stress
MH  - Proteomics
MH  - Transcriptome
PMC - PMC3544078
MID - NIHMS424736
EDAT- 2012/12/12 06:00
MHDA- 2013/05/23 06:00
PMCR- 2013/12/05
CRDT- 2012/12/11 06:00
PHST- 2012/05/23 00:00 [received]
PHST- 2012/09/10 00:00 [revised]
PHST- 2012/11/06 00:00 [accepted]
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/05/23 06:00 [medline]
PHST- 2013/12/05 00:00 [pmc-release]
AID - S1550-4131(12)00456-1 [pii]
AID - 10.1016/j.cmet.2012.11.003 [doi]
PST - ppublish
SO  - Cell Metab. 2012 Dec 5;16(6):777-88. doi: 10.1016/j.cmet.2012.11.003.