PMID- 23217315
OWN - NLM
STAT- MEDLINE
DCOM- 20130429
LR  - 20131121
IS  - 1873-376X (Electronic)
IS  - 1570-0232 (Linking)
VI  - 911
DP  - 2012 Dec 12
TI  - Metabolism studies of benzbromarone in rats by high performance liquid 
      chromatography-quadrupole time of flight mass spectrometry.
PG  - 122-32
LID - S1570-0232(12)00626-5 [pii]
LID - 10.1016/j.jchromb.2012.10.035 [doi]
AB  - A high performance liquid chromatography-quadrupole time of flight mass 
      spectrometry (HPLC-QTOF-MS) method was employed in investigation of benzbromarone 
      metabolites in rat plasma, urine, feces and bile samples. Meanwhile, the 
      metabolic pathways of benzbromarone in rats were discussed. The identification 
      was achieved on a reversed-phase C(18) column with mobile phase gradient method. 
      The QTOF-MS was operated under full scan of MS or MS/MS in negative mode. The 
      fragments were acquired by raising collision induced dissociation (CID) energy 
      for speculating the structures of parent ions. According to the information from 
      the chromatograms and mass spectra, 17 metabolites were obtained. Among them, the 
      deoxidized phase I metabolites and an array of phase II metabolites-sulfate 
      conjugates detected in the biological samples made the work more significant.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Wu, Haiqing
AU  - Wu H
AD  - Department of Pharmacy, Shenyang Pharmaceutical University, 103 Wen-Hua Road, 
      Shenyang 110016, China.
FAU - Peng, Ying
AU  - Peng Y
FAU - Wang, Shaojie
AU  - Wang S
FAU - Wang, Kai
AU  - Wang K
FAU - Zhao, Xunchen
AU  - Zhao X
FAU - Jiang, Fan
AU  - Jiang F
LA  - eng
PT  - Journal Article
DEP - 20121102
PL  - Netherlands
TA  - J Chromatogr B Analyt Technol Biomed Life Sci
JT  - Journal of chromatography. B, Analytical technologies in the biomedical and life 
      sciences
JID - 101139554
RN  - 0 (Bile Acids and Salts)
RN  - 0 (Glucuronides)
RN  - 0 (Sulfates)
RN  - 4POG0RL69O (Benzbromarone)
SB  - IM
MH  - Animals
MH  - Benzbromarone/analogs & derivatives/analysis/chemistry/*metabolism
MH  - Bile Acids and Salts/chemistry
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Feces/chemistry
MH  - Glucuronides/analysis/chemistry/metabolism
MH  - Male
MH  - Mass Spectrometry/*methods
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sulfates/analysis/chemistry/metabolism
EDAT- 2012/12/12 06:00
MHDA- 2013/04/30 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/06/14 00:00 [received]
PHST- 2012/10/15 00:00 [revised]
PHST- 2012/10/25 00:00 [accepted]
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/04/30 06:00 [medline]
AID - S1570-0232(12)00626-5 [pii]
AID - 10.1016/j.jchromb.2012.10.035 [doi]
PST - ppublish
SO  - J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Dec 12;911:122-32. doi: 
      10.1016/j.jchromb.2012.10.035. Epub 2012 Nov 2.