PMID- 23217877
OWN - NLM
STAT- MEDLINE
DCOM- 20130628
LR  - 20121211
IS  - 1531-5037 (Electronic)
IS  - 0022-3468 (Linking)
VI  - 47
IP  - 12
DP  - 2012 Dec
TI  - The prognostic significance of blastemal predominant histology in initially 
      resected Wilms' tumors: a report from the Study Group for Pediatric Solid Tumors 
      in the Kyushu Area, Japan.
PG  - 2205-9
LID - S0022-3468(12)00711-7 [pii]
LID - 10.1016/j.jpedsurg.2012.09.009 [doi]
AB  - BACKGROUND AND PURPOSE: The strategy used to treat pediatric renal tumors in 
      Japan is based on the Japanese Wilms' Tumor Study (JWiTS) protocol, which was 
      based on the National Wilms' Tumor Study (NWTS)-5 regimen. The regimen is 
      characterized by an initial radical operation, followed by adjuvant chemotherapy 
      and radiotherapy. Concerning the histological classification, a new 
      classification based on the International Society of Pediatric Oncology (SIOP) 
      classification was used beginning in 2008. The main points of revision are that 
      the "blastemal predominant type" was classified as an independent category in the 
      Wilms' tumor subtypes. The purpose of this study was to analyze the biological 
      characteristics from the standpoint of the newly established histological 
      classification. MATERIALS AND METHODS: From 1971 to 2005, 174 cases of Wilms' 
      tumors treated with an initial operation followed by adjuvant therapy were 
      re-evaluated by the new histological classification. Histologically, all these 
      materials showed no secondary changes associated with adjuvant therapy. RESULTS: 
      According to the new classification, Wilms' tumors were classified into four 
      subtypes, including the mixed type (n=112), epithelial type (n=17), mesenchymal 
      type (n=15), and blastemal predominant type (n=26). The 5 year overall survival 
      rates were as follows; mixed type (90.1%), epithelial type (100%), mesenchymal 
      type (93.3%), and blastemal predominant type (65.4%). CONCLUSION: The patients 
      with blastemal predominant tumors demonstrated a significantly worse prognosis 
      compared with those of other subtypes. The treatment strategy of blastemal 
      predominant category should be distinguished from the other favorable subtypes.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Kinoshita, Yoshiaki
AU  - Kinoshita Y
AD  - The Committee for Pediatric Solid Malignant Tumors in Kyushu area, Japan. 
      kinoppy@pedsurg.med.kyushu-u.ac.jp
FAU - Suminoe, Aiko
AU  - Suminoe A
FAU - Inada, Hiroko
AU  - Inada H
FAU - Yagi, Minoru
AU  - Yagi M
FAU - Yanai, Fumio
AU  - Yanai F
FAU - Zaizen, Yoshio
AU  - Zaizen Y
FAU - Nishi, Masanori
AU  - Nishi M
FAU - Inomata, Yukihiro
AU  - Inomata Y
FAU - Kawakami, Kiyoshi
AU  - Kawakami K
FAU - Matsufuji, Hiroshi
AU  - Matsufuji H
FAU - Suenobu, Souichi
AU  - Suenobu S
FAU - Handa, Noritoshi
AU  - Handa N
FAU - Kohashi, Kenichi
AU  - Kohashi K
FAU - Oda, Yoshinao
AU  - Oda Y
FAU - Hara, Toshiro
AU  - Hara T
FAU - Taguchi, Tomoaki
AU  - Taguchi T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Pediatr Surg
JT  - Journal of pediatric surgery
JID - 0052631
SB  - IM
MH  - Antineoplastic Combined Chemotherapy Protocols
MH  - Biopsy, Needle
MH  - Chemoradiotherapy, Adjuvant
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Combined Modality Therapy/methods
MH  - Databases, Factual
MH  - Disease-Free Survival
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Infant
MH  - Japan
MH  - Kidney Neoplasms/mortality/*pathology/*therapy
MH  - Male
MH  - Neoplasm Invasiveness/pathology
MH  - Neoplasm Staging
MH  - Nephrectomy/*methods
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Survival Analysis
MH  - Treatment Outcome
MH  - Wilms Tumor/mortality/*pathology/*therapy
EDAT- 2012/12/12 06:00
MHDA- 2013/07/03 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/08/25 00:00 [received]
PHST- 2012/09/01 00:00 [accepted]
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/07/03 06:00 [medline]
AID - S0022-3468(12)00711-7 [pii]
AID - 10.1016/j.jpedsurg.2012.09.009 [doi]
PST - ppublish
SO  - J Pediatr Surg. 2012 Dec;47(12):2205-9. doi: 10.1016/j.jpedsurg.2012.09.009.