PMID- 23218823
OWN - NLM
STAT- MEDLINE
DCOM- 20130801
LR  - 20220316
IS  - 1549-4713 (Electronic)
IS  - 0161-6420 (Linking)
VI  - 120
IP  - 3
DP  - 2013 Mar
TI  - Reversal of lamina cribrosa displacement after intraocular pressure reduction in 
      open-angle glaucoma.
PG  - 553-559
LID - S0161-6420(12)00875-5 [pii]
LID - 10.1016/j.ophtha.2012.08.047 [doi]
AB  - PURPOSE: To compare the change in lamina cribrosa (LC) displacement in response 
      to intraocular pressure (IOP) lowering in patients with open-angle glaucoma (OAG) 
      using spectral-domain optical coherence tomography (SD-OCT). DESIGN: 
      Observational case series. PARTICIPANTS: One hundred eyes of 100 patients with 
      OAG in whom IOP at the follow-up examination had decreased by at least 20% 
      compared with the baseline IOP. METHODS: Serial horizontal B-scan images of the 
      optic nerve head (ONH) were obtained from each eye using enhanced depth imaging 
      SD-OCT. Approximately 65 B-scans covering the optic discs were obtained before 
      and 3 to 6 months after lowering IOP. The baseline and follow-up LC depths (the 
      distance from the Bruch's membrane opening plane to the level of the anterior LC 
      surface) were measured in B-scan images from each eye. MAIN OUTCOME MEASURES: The 
      mean and maximum amount of reductions in LC depth measured in the 7 selected 
      B-scan images. RESULTS: Intraocular pressure decreased from 21.2+/-9.1 to 10.5+/-2.6 
      mmHg. The percent of IOP reduction was significantly related to the untreated IOP 
      (P < 0.001). There was a significant decrease in the LC depth at the follow-up 
      examination compared with the baseline value (P < 0.001). The magnitude of LC 
      depth reduction was significantly associated with younger age, higher untreated 
      IOP, higher baseline IOP, and greater percent of IOP reduction (all P < 0.02). 
      CONCLUSIONS: Reversal of the LC displacement was observed after IOP-lowering 
      treatment in OAG. The degree of LC displacement reversal was related to the 
      amount of IOP lowering.
CI  - Copyright (c) 2013 American Academy of Ophthalmology. Published by Elsevier Inc. 
      All rights reserved.
FAU - Lee, Eun Ji
AU  - Lee EJ
AD  - Department of Ophthalmology, Seoul National University College of Medicine, Seoul 
      National University Bundang Hospital, Seongnam, Korea.
FAU - Kim, Tae-Woo
AU  - Kim TW
AD  - Department of Ophthalmology, Seoul National University College of Medicine, Seoul 
      National University Bundang Hospital, Seongnam, Korea. Electronic address: 
      twkim7@snu.ac.kr.
FAU - Weinreb, Robert N
AU  - Weinreb RN
AD  - Hamilton Glaucoma Center and Shiley Eye Center, Department of Ophthalmology, 
      University of California San Diego, La Jolla, California.
FAU - Kim, Hyunjoong
AU  - Kim H
AD  - Department of Applied Statistics, Yonsei University, Seoul, Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121206
PL  - United States
TA  - Ophthalmology
JT  - Ophthalmology
JID - 7802443
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Glaucoma, Open-Angle/*physiopathology/surgery
MH  - Gonioscopy
MH  - Humans
MH  - Intraocular Pressure/*physiology
MH  - Male
MH  - Middle Aged
MH  - Optic Disk/*physiopathology
MH  - Optic Nerve Diseases/*physiopathology
MH  - Tomography, Optical Coherence
MH  - Tonometry, Ocular
MH  - Trabeculectomy
MH  - Visual Acuity/physiology
MH  - Visual Field Tests
MH  - Visual Fields
MH  - Young Adult
EDAT- 2012/12/12 06:00
MHDA- 2013/08/02 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/04/25 00:00 [received]
PHST- 2012/08/05 00:00 [revised]
PHST- 2012/08/06 00:00 [accepted]
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/08/02 06:00 [medline]
AID - S0161-6420(12)00875-5 [pii]
AID - 10.1016/j.ophtha.2012.08.047 [doi]
PST - ppublish
SO  - Ophthalmology. 2013 Mar;120(3):553-559. doi: 10.1016/j.ophtha.2012.08.047. Epub 
      2012 Dec 6.