PMID- 23219067
OWN - NLM
STAT- MEDLINE
DCOM- 20130404
LR  - 20220331
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Print)
IS  - 0002-9394 (Linking)
VI  - 155
IP  - 3
DP  - 2013 Mar
TI  - Reactive retinal astrocytic tumors (so-called vasoproliferative tumors): 
      histopathologic, immunohistochemical, and genetic studies of four cases.
PG  - 593-608.e1
LID - S0002-9394(12)00616-2 [pii]
LID - 10.1016/j.ajo.2012.09.002 [doi]
AB  - PURPOSE: To evaluate the cellular nature of and diagnostic terminology used in 
      connection with acquired retinal "vasoproliferative tumors." DESIGN: 
      Retrospective clinicopathologic study. METHODS: Clinical records and microscopic 
      slides of 4 enucleated globes were reviewed. Special stains and 
      immunohistochemical probes for CD31, CD34, p53, glial fibrillary acidic protein 
      (GFAP), CD163, and Ki67 (cell replication) were employed; ultrastructural and 
      fluorescence in situ hybridization (FISH) analyses were performed. RESULTS: 
      Tumors were located inferotemporally in middle-aged patients. They were uniformly 
      composed of compacted elongated, GFAP-positive spindle cells (due to intermediate 
      filaments identified ultrastructurally) with a Ki67 index of less than 1%. 
      Rosenthal fibers and eosinophilic granular bodies were observed. Hyalinized 
      periodic acid-Schiff-positive vessels were widely separated. CD31 and CD34 
      revealed a sparse microvasculature. Tumor-associated exudate spread predominantly 
      subretinally. The retinal pigment epithelium had undergone extensive placoid 
      fibrous metaplasia with focal ossification. P53 upregulation, BRAF-KIAA gene 
      rearrangement, and IDH1R132H mutation typically associated with low-grade 
      astrocytic neoplasms were absent. CONCLUSIONS: Retinal "vasoproliferative" tumors 
      have been mischaracterized, because they actually display a paucity of 
      microvessels. Proliferating fibrous astrocytes with a very low proliferation 
      index predominate, without immunohistochemical or genetic evidence favoring a 
      neoplasm. Subretinal exudate appeared capable of provoking widespread fibrous 
      metaplasia of the pigment epithelium that was mainly responsible for secondary 
      retinal damage. The term "reactive retinal astrocytic tumor" is proposed as more 
      appropriate for this entity. In carefully selected progressive lesions, 
      consideration should be given to earlier surgical intervention before extensive 
      subretinal exudate accumulates and pigment epithelial proliferation with fibrous 
      metaplasia ensues.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Poole Perry, Lynn J
AU  - Poole Perry LJ
AD  - Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical 
      School, Boston, MA, USA.
FAU - Jakobiec, Frederick A
AU  - Jakobiec FA
FAU - Zakka, Fouad R
AU  - Zakka FR
FAU - Reichel, Elias
AU  - Reichel E
FAU - Herwig, Martina C
AU  - Herwig MC
FAU - Perry, Arie
AU  - Perry A
FAU - Brat, Daniel J
AU  - Brat DJ
FAU - Grossniklaus, Hans E
AU  - Grossniklaus HE
LA  - eng
GR  - P30 EY006360/EY/NEI NIH HHS/United States
GR  - P30 EY06360/EY/NEI NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20121206
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
RN  - 0 (BRAF-KIAA1549 fusion protein, human)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - EC 1.1.1.41 (Isocitrate Dehydrogenase)
RN  - EC 1.1.1.42. (IDH1 protein, human)
SB  - IM
CIN - Am J Ophthalmol. 2013 Jul;156(1):202-3. PMID: 23791372
CIN - Am J Ophthalmol. 2013 Jul;156(1):203. PMID: 23791373
MH  - Adult
MH  - Aged
MH  - Astrocytes/metabolism/ultrastructure
MH  - *Astrocytoma/genetics/metabolism/pathology
MH  - Biomarkers, Tumor/*metabolism
MH  - Eye Enucleation
MH  - Female
MH  - Gene Rearrangement
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Isocitrate Dehydrogenase/*genetics
MH  - Male
MH  - Neoplasm Proteins/*metabolism
MH  - Oncogene Proteins, Fusion/*genetics
MH  - Polymerase Chain Reaction
MH  - *Retinal Neoplasms/genetics/metabolism/pathology
MH  - Retrospective Studies
MH  - Terminology as Topic
PMC - PMC4470612
MID - NIHMS698650
EDAT- 2012/12/12 06:00
MHDA- 2013/04/05 06:00
PMCR- 2015/06/17
CRDT- 2012/12/11 06:00
PHST- 2012/06/28 00:00 [received]
PHST- 2012/08/30 00:00 [revised]
PHST- 2012/09/04 00:00 [accepted]
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/04/05 06:00 [medline]
PHST- 2015/06/17 00:00 [pmc-release]
AID - S0002-9394(12)00616-2 [pii]
AID - 10.1016/j.ajo.2012.09.002 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2013 Mar;155(3):593-608.e1. doi: 10.1016/j.ajo.2012.09.002. Epub 
      2012 Dec 6.