PMID- 23219101 OWN - NLM STAT- MEDLINE DCOM- 20140402 LR - 20130902 IS - 1872-7123 (Electronic) IS - 0165-1781 (Linking) VI - 209 IP - 2 DP - 2013 Sep 30 TI - Lifestyle modification and behavior therapy effectively reduce body weight and increase serum level of brain-derived neurotrophic factor in obese non-diabetic patients with schizophrenia. PG - 150-4 LID - S0165-1781(12)00770-6 [pii] LID - 10.1016/j.psychres.2012.11.020 [doi] AB - The goal of the study was to elucidate the relationship between serum circulating brain-derived neurotrophic factor (BDNF) and body weight reduction via lifestyle modification and behavior therapy in obese non-diabetic patients with chronic schizophrenia. Thirty-three obese non-diabetic subjects with schizophrenia treated with stable antipsychotic medication in a day-care unit for at least 3 months were recruited. Thirty age-, body weight-matched subjects without psychiatric disorders were enrolled as controls. All participants underwent a 10-week weight reduction program, including lifestyle modification, psychosocial treatment, behavior therapy and exercise in the day-care unit. Blood biochemistry, serum BDNF, adipokine (adiponectin), inflammatory markers (C-reactive protein, tumor necrosis factor-alpha and interleukin-6) and oral glucose tolerance test were evaluated before and after the program. Serum BDNF concentrations were significantly lower among patients with schizophrenia compared to control subjects. Serum BDNF levels were significantly increased following the weight reduction program. Elevations in serum BDNF levels were positively correlated with body weight and body mass index reduction. Altogether, our results demonstrate that a non-pharmacological weight reduction program effectively reduces body weight with significant elevation of serum BDNF levels in obese non-diabetic patients with schizophrenia. CI - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved. FAU - Kuo, Feng-Chih AU - Kuo FC AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. FAU - Lee, Chien-Hsing AU - Lee CH FAU - Hsieh, Chang-Hsun AU - Hsieh CH FAU - Kuo, Philip AU - Kuo P FAU - Chen, Yi-Chyan AU - Chen YC FAU - Hung, Yi-Jen AU - Hung YJ LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20121206 PL - Ireland TA - Psychiatry Res JT - Psychiatry research JID - 7911385 RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Adolescent MH - Adult MH - Behavior Therapy/*methods MH - Body Mass Index MH - Body Weight/*physiology MH - Brain-Derived Neurotrophic Factor/*blood MH - Female MH - Glucose Tolerance Test MH - Humans MH - Life Style MH - Male MH - Middle Aged MH - *Obesity/blood/complications/rehabilitation MH - *Schizophrenia/blood/complications/rehabilitation MH - *Schizophrenic Psychology MH - Statistics, Nonparametric MH - Young Adult OTO - NOTNLM OT - Body weight reduction OT - Brain-derived neurotrophic factor OT - Obesity OT - Schizophrenia EDAT- 2012/12/12 06:00 MHDA- 2014/04/03 06:00 CRDT- 2012/12/11 06:00 PHST- 2012/04/03 00:00 [received] PHST- 2012/09/30 00:00 [revised] PHST- 2012/11/12 00:00 [accepted] PHST- 2012/12/11 06:00 [entrez] PHST- 2012/12/12 06:00 [pubmed] PHST- 2014/04/03 06:00 [medline] AID - S0165-1781(12)00770-6 [pii] AID - 10.1016/j.psychres.2012.11.020 [doi] PST - ppublish SO - Psychiatry Res. 2013 Sep 30;209(2):150-4. doi: 10.1016/j.psychres.2012.11.020. Epub 2012 Dec 6.