PMID- 23219910
OWN - NLM
STAT- MEDLINE
DCOM- 20130725
LR  - 20130129
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 231
DP  - 2013 Feb 12
TI  - Ipsilateral versus contralateral spontaneous post-stroke neuroplastic changes: 
      involvement of BDNF?
PG  - 169-81
LID - S0306-4522(12)01165-7 [pii]
LID - 10.1016/j.neuroscience.2012.11.054 [doi]
AB  - Stroke is a leading cause of death and disability in industrialized countries. 
      Although surviving patients exhibit a certain degree of restoration of function 
      attributable to brain plasticity, the majority of stroke survivors has to 
      struggle with persisting deficits. In order to potentiate post-stroke recovery, 
      several rehabilitation therapies have been undertaken and many experimental 
      studies have reported that brain-derived neurotrophic factor (BDNF) is central to 
      many facets of neuroplastic processes. However, although BDNF role in brain 
      plasticity is well characterized through strategies that manipulate its content, 
      the involvement of this neurotrophin in spontaneous post-stroke recovery remains 
      to be clarified. Besides, while the neuroplastic role of BDNF is restricted to 
      its mature form, most studies investigating the proper effect of ischemia on 
      post-stroke BDNF metabolism focused on mRNA or total protein expressions. In 
      addition, these studies are mainly performed in brain regions collected either at 
      or around the lesion site. Therefore, the objective of the present study was to 
      investigate in both hemispheres, the long-term expression (up to one month) of 
      both pro- and mature BDNF forms in rats subjected to photothrombotic ischemia. 
      These assessments were performed in the cortex and in the hippocampus, two 
      regions known to subserve functional recovery after stroke and were coupled to 
      the study of synaptophysin expression, a marker of synaptogenesis. Our study 
      reports that stroke induces an early and transient increase (4h) in mature BDNF 
      expression in the cortex of both hemispheres that was associated with a delayed 
      rise (30d) in synaptophysin levels ipsilateraly. In both hippocampal territories, 
      the pattern of mature BDNF expression shows a more delayed increase (from 8 to 
      30d), which coincides with the evolution of synaptophysin expression. 
      Interestingly, in these hippocampal territories, pro-BDNF levels evolve 
      differently suggesting a differential gene regulation between the two 
      hemispheres. While highlighting the complexity of changes in BDNF metabolism 
      after stroke, our data suggest that BDNF involvement in spontaneous post-stroke 
      plasticity is region-dependent.
CI  - Copyright (c) 2012 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Madinier, A
AU  - Madinier A
AD  - Unite INSERM U1093 Cognition, Action et Plasticite Sensorimotrice, Dijon F-21078, 
      France.
FAU - Bertrand, N
AU  - Bertrand N
FAU - Rodier, M
AU  - Rodier M
FAU - Quirie, A
AU  - Quirie A
FAU - Mossiat, C
AU  - Mossiat C
FAU - Prigent-Tessier, A
AU  - Prigent-Tessier A
FAU - Marie, C
AU  - Marie C
FAU - Garnier, P
AU  - Garnier P
LA  - eng
PT  - Journal Article
DEP - 20121207
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Synaptophysin)
SB  - IM
MH  - Animals
MH  - Brain/*metabolism/physiopathology
MH  - Brain Ischemia/*metabolism/physiopathology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Male
MH  - Neuronal Plasticity/*physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Stroke/*metabolism/physiopathology
MH  - Synaptophysin/metabolism
MH  - Time Factors
EDAT- 2012/12/12 06:00
MHDA- 2013/07/26 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/07/24 00:00 [received]
PHST- 2012/11/15 00:00 [revised]
PHST- 2012/11/28 00:00 [accepted]
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/07/26 06:00 [medline]
AID - S0306-4522(12)01165-7 [pii]
AID - 10.1016/j.neuroscience.2012.11.054 [doi]
PST - ppublish
SO  - Neuroscience. 2013 Feb 12;231:169-81. doi: 10.1016/j.neuroscience.2012.11.054. 
      Epub 2012 Dec 7.