PMID- 23221577
OWN - NLM
STAT- MEDLINE
DCOM- 20130319
LR  - 20230318
IS  - 1938-3207 (Electronic)
IS  - 0002-9165 (Print)
IS  - 0002-9165 (Linking)
VI  - 97
IP  - 2
DP  - 2013 Feb
TI  - Effect of coenzyme Q(1)(0) supplementation on heart failure: a meta-analysis.
PG  - 268-75
LID - 10.3945/ajcn.112.040741 [doi]
AB  - BACKGROUND: Coenzyme Q(1)(0) (CoQ(1)(0); also called ubiquinone) is an antioxidant that 
      has been postulated to improve functional status in congestive heart failure 
      (CHF). Several randomized controlled trials have examined the effects of CoQ(1)(0) on 
      CHF with inconclusive results. OBJECTIVE: The objective of this meta-analysis was 
      to evaluate the impact of CoQ(1)(0) supplementation on the ejection fraction (EF) and 
      New York Heart Association (NYHA) functional classification in patients with CHF. 
      DESIGN: A systematic review of the literature was conducted by using databases 
      including MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, 
      and manual examination of references from selected studies. Studies included were 
      randomized controlled trials of CoQ(1)(0) supplementation that reported the EF or 
      NYHA functional class as a primary outcome. Information on participant 
      characteristics, trial design and duration, treatment, dose, control, EF, and 
      NYHA classification were extracted by using a standardized protocol. RESULTS: 
      Supplementation with CoQ(1)(0) resulted in a pooled mean net change of 3.67% (95% CI: 
      1.60%, 5.74%) in the EF and -0.30 (95% CI: -0.66, 0.06) in the NYHA functional 
      class. Subgroup analyses showed significant improvement in EF for crossover 
      trials, trials with treatment duration </=12 wk in length, studies published before 
      1994, and studies with a dose </=100 mg CoQ(1)(0)/d and in patients with less severe 
      CHF. These subgroup analyses should be interpreted cautiously because of the 
      small number of studies and patients included in each subgroup. CONCLUSIONS: 
      Pooled analyses of available randomized controlled trials suggest that CoQ(1)(0) may 
      improve the EF in patients with CHF. Additional well-designed studies that 
      include more diverse populations are needed.
FAU - Fotino, A Domnica
AU  - Fotino AD
AD  - Department of Medicine, School of Medicine, Tulane University, New Orleans, LA 
      70112, USA. dfotino@tulane.edu
FAU - Thompson-Paul, Angela M
AU  - Thompson-Paul AM
FAU - Bazzano, Lydia A
AU  - Bazzano LA
LA  - eng
GR  - K08 HL091108/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
DEP - 20121205
PL  - United States
TA  - Am J Clin Nutr
JT  - The American journal of clinical nutrition
JID - 0376027
RN  - 1339-63-5 (Ubiquinone)
RN  - EJ27X76M46 (coenzyme Q10)
SB  - IM
CIN - Am J Clin Nutr. 2013 Feb;97(2):233-4. PMID: 23325068
MH  - Adult
MH  - *Dietary Supplements
MH  - Heart Failure/*diet therapy/physiopathology
MH  - Humans
MH  - Randomized Controlled Trials as Topic
MH  - Severity of Illness Index
MH  - Stroke Volume
MH  - Ubiquinone/*analogs & derivatives/therapeutic use
MH  - Ventricular Dysfunction, Left/etiology/*prevention & control
PMC - PMC3742297
EDAT- 2012/12/12 06:00
MHDA- 2013/03/21 06:00
PMCR- 2014/02/01
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/03/21 06:00 [medline]
PHST- 2014/02/01 00:00 [pmc-release]
AID - S0002-9165(23)05406-0 [pii]
AID - 040741 [pii]
AID - 10.3945/ajcn.112.040741 [doi]
PST - ppublish
SO  - Am J Clin Nutr. 2013 Feb;97(2):268-75. doi: 10.3945/ajcn.112.040741. Epub 2012 
      Dec 5.