PMID- 23221871
OWN - NLM
STAT- MEDLINE
DCOM- 20130606
LR  - 20221207
IS  - 1423-0224 (Electronic)
IS  - 0302-282X (Linking)
VI  - 67
IP  - 1
DP  - 2013
TI  - Gender-specific effects of brain-derived neurotrophic factor Val66Met 
      polymorphism and childhood maltreatment on anxiety.
PG  - 6-13
LID - 10.1159/000342384 [doi]
AB  - BACKGROUND: Although the brain-derived neurotrophic factor (BDNF) Val66Met 
      polymorphism is thought to play an important role in the pathophysiology of 
      anxiety, studies on the association between the BDNF polymorphism and anxiety 
      have reported inconsistent results. As possible confounders in determining 
      anxiety, childhood maltreatment and gender as well as their interactions with 
      BDNF polymorphism have been suggested. This study examined the effect of BDNF 
      genotype, childhood maltreatment, and their interaction on anxiety levels by 
      gender. METHODS: A total of 206 unrelated Korean healthy young adults (108 were 
      male and the mean age was 23.1 +/- 3.2 years) were genotyped for the BDNFVal66Met 
      polymorphism. Measures for anxiety and childhood maltreatment were completed. The 
      main and interaction effects of BDNF polymorphism and childhood maltreatment on 
      anxiety were analyzed by general linear models in all subjects and then in 
      gender-stratified groups. RESULTS: Gender-specific analyses revealed that the 
      interaction effect was significant only in males (p = 0.014). Interestingly, male 
      subjects with the Val/Met genotype tended to be resilient against the increased 
      anxiety after childhood maltreatment. In females, the main effects of both BDNF 
      genotype and childhood maltreatment were significant (p = 0.024 and p = 0.009, 
      respectively) and post-hoc analysis revealed that the Val/Val genotype was 
      associated with a higher anxiety than the Met/Met genotype (p = 0.004). 
      CONCLUSIONS: Our results support the interaction effect between the BDNFVal66Met 
      polymorphism and childhood maltreatment in determining anxiety and further 
      emphasize the possible moderating role of gender in this gene-environment 
      interaction.
CI  - Copyright (c) 2012 S. Karger AG, Basel.
FAU - Min, Jung-Ah
AU  - Min JA
AD  - Department of Psychiatry, Seoul St. Mary's Hospital, Catholic University of 
      Korea, College of Medicine, Seoul, Republic of Korea.
FAU - Lee, Heon-Jeong
AU  - Lee HJ
FAU - Lee, Seung-Hwan
AU  - Lee SH
FAU - Park, Young-Min
AU  - Park YM
FAU - Kang, Seung-Gul
AU  - Kang SG
FAU - Chae, Jeong-Ho
AU  - Chae JH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121204
PL  - Switzerland
TA  - Neuropsychobiology
JT  - Neuropsychobiology
JID - 7512895
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Adult Survivors of Child Abuse/*psychology
MH  - Anxiety/*genetics/*psychology
MH  - Asian People/genetics/psychology
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - *Gene-Environment Interaction
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Polymorphism, Single Nucleotide/drug effects
MH  - Sex Characteristics
EDAT- 2012/12/12 06:00
MHDA- 2013/06/07 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/04/20 00:00 [received]
PHST- 2012/08/06 00:00 [accepted]
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/06/07 06:00 [medline]
AID - 000342384 [pii]
AID - 10.1159/000342384 [doi]
PST - ppublish
SO  - Neuropsychobiology. 2013;67(1):6-13. doi: 10.1159/000342384. Epub 2012 Dec 4.