PMID- 23221974
OWN - NLM
STAT- MEDLINE
DCOM- 20130606
LR  - 20221207
IS  - 1423-0224 (Electronic)
IS  - 0302-282X (Linking)
VI  - 67
IP  - 1
DP  - 2013
TI  - Metabolic and glutathione redox markers associated with brain-derived 
      neurotrophic factor in depressed african men and women: evidence for 
      counterregulation?
PG  - 33-40
LID - 10.1159/000343501 [doi]
AB  - BACKGROUND: Major depression is associated with evidence for metabolic and redox 
      imbalance and also with reports of lower serum levels of brain-derived 
      neurotrophic factor (BDNF). However, the relationship between these factors has 
      not been well studied. METHODS: We studied the contribution of physiological risk 
      factors to cardiometabolic health in 200 adult male and female black Africans, 
      aged between 36 and 52 years, presenting with (n = 89) and without (n = 111) 
      symptoms of depression. Specifically the association between serum BDNF and 
      markers of basal metabolic and redox status in depressed versus nondepressed 
      individuals were analyzed. RESULTS: BDNF and markers of redox and metabolic 
      status were not associated with the symptoms of depression. Waist circumference, 
      a metabolic risk factor, was positively associated with BDNF and accounts for 49% 
      of the variance in BDNF in depressed men. Reduced and oxidized glutathione were 
      positively and negatively correlated with BDNF in depressed women, respectively, 
      with glutathione redox status accounting for 36-42% of the variance in BDNF. 
      CONCLUSION: Selected metabolic and redox factors explained gender-specific 
      variances in serum BDNF levels in depressed African men and women. Our findings 
      suggest that changes in redox and metabolic status may represent 
      counterregulation by BDNF or alternatively that BDNF may mediate undesirable 
      redox and metabolic changes that are associated with the development of a mood 
      disorder.
CI  - Copyright (c) 2012 S. Karger AG, Basel.
FAU - Harvey, Brian H
AU  - Harvey BH
AD  - Unit for Drug Research and Development, Division of Pharmacology, School for 
      Pharmacy, North-West University, Potchefstroom, South Africa. 
      Brian.Harvey@nwu.ac.za
FAU - Hamer, Mark
AU  - Hamer M
FAU - Louw, Roan
AU  - Louw R
FAU - van der Westhuizen, Francois H
AU  - van der Westhuizen FH
FAU - Malan, Leone
AU  - Malan L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121204
PL  - Switzerland
TA  - Neuropsychobiology
JT  - Neuropsychobiology
JID - 7512895
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Adult
MH  - *Basal Metabolism
MH  - Biomarkers/blood
MH  - Black People/*psychology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Case-Control Studies
MH  - Depressive Disorder, Major/blood/*metabolism
MH  - Female
MH  - Glutathione/*metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oxidation-Reduction
MH  - Psychiatric Status Rating Scales/statistics & numerical data
MH  - Risk Factors
MH  - Sex Characteristics
MH  - South Africa
MH  - Waist Circumference
EDAT- 2012/12/12 06:00
MHDA- 2013/06/07 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/05/25 00:00 [received]
PHST- 2012/09/10 00:00 [accepted]
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/06/07 06:00 [medline]
AID - 000343501 [pii]
AID - 10.1159/000343501 [doi]
PST - ppublish
SO  - Neuropsychobiology. 2013;67(1):33-40. doi: 10.1159/000343501. Epub 2012 Dec 4.