PMID- 23222800
OWN - NLM
STAT- MEDLINE
DCOM- 20140219
LR  - 20170306
VI  - 122 Suppl 1
DP  - 2012
TI  - Autoimmune thyroid diseases and nonorgan‑specific autoimmunity.
PG  - 55-9
AB  - Autoimmune thyroid diseases (ATD), as the most common organ‑specific autoimmune 
      disorder, is frequently accompanied by other organ- and nonorgan‑specific 
      autoimmune diseases. Although the exact pathogenic mechanism of the coexistence 
      of autoimmune disorders has not been clearly defined, genetic and environmental 
      factors, immune defects, and hormonal changes, may play a key role in 
      polyautoimmunity. The role of human leukocyte antigen (HLA) haplotypes, HLA-B8 
      and -DR3, in the overlapping of autoimmune disorders was well supported by higher 
      frequency of these haplotypes in primary Sjogren's syndrome (PSS) and ATD. In 
      addition, polymorphisms of the cytotoxic T lymphocytic antigen 4 gene have been 
      reported to be associated with many autoimmune disorders especially those 
      coexisting with ATD. Definite noncasual association of ATD has been clearly 
      documented in patients with PSS, rheumatoid arthritis, and systemic lupus 
      erythematosus. Possible association with ATD is also considered in systemic 
      sclerosis and dermatomyositis. Many authors documented a significantly higher 
      prevalence of antinuclear antibodies (ANAs) in ATD patients in comparison with 
      controls; however, the clinical significance of ANAs in this group is still 
      unknown. The presence of other non‑organ‑specific antibodies has not been 
      convincingly demonstrated. On the other hand, the prevalence of antithyroid 
      antibodies as well as ATD is higher in patients with systemic connective tissue 
      disease compared with the general population. Basedon these data, there is no 
      evidence for the utility of ANA testing in patients with ATD, but because of the 
      high prevalence of ATD and antithyroid autoantibodies, it is clinically important 
      to screen patients with autoimmune rheumatic disorders for the presence of 
      thyroid autoimmunity.
FAU - Lazurova, Ivica
AU  - Lazurova I
AD  - 1st Department of Internal Medicine, Faculty of Medicine, Pavol Jozef Safarik 
      University in Kosice, Kosice, Slovakia. ivica.lazurova@upjs.sk
FAU - Benhatchi, Karim
AU  - Benhatchi K
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Poland
TA  - Pol Arch Med Wewn
JT  - Polskie Archiwum Medycyny Wewnetrznej
JID - 0401225
SB  - IM
MH  - Arthritis, Rheumatoid/*immunology
MH  - Humans
MH  - Lupus Vasculitis, Central Nervous System/*immunology
MH  - Sjogren's Syndrome/*immunology
MH  - Thyroiditis, Autoimmune/genetics/*immunology
EDAT- 2012/12/19 06:00
MHDA- 2014/02/20 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/19 06:00 [pubmed]
PHST- 2014/02/20 06:00 [medline]
PST - ppublish
SO  - Pol Arch Med Wewn. 2012;122 Suppl 1:55-9.