PMID- 23224211
OWN - NLM
STAT- MEDLINE
DCOM- 20140310
LR  - 20211021
IS  - 1433-0423 (Electronic)
IS  - 0941-293X (Linking)
VI  - 110
IP  - 8
DP  - 2013 Aug
TI  - [Cytokine determination from vitreous samples in retinal vascular diseases].
PG  - 746-54
LID - 10.1007/s00347-012-2719-4 [doi]
AB  - PURPOSE: The aim of this study was to determine cytokine levels from vitreous 
      samples of treatment-naive patients with diabetic retinopathy (DRP), retinal vein 
      occlusion (RVO) and exudative age-related macular degeneration (ARMD). METHODS: 
      In this study 187 patients (median age 67 years, 101 males) were treated with a 
      combined drug therapy including a 23-gauge core vitrectomy. Interleukin-6 (IL-6), 
      monocyte chemoattractant protein-1 (MCP-1) and intravitreal vascular endothelial 
      growth factor (VEGF-A) levels were determined a using cytometric bead assay (CBA) 
      and compared to those of the control group. RESULTS: Compared to the control 
      group all diseases had significantly elevated cytokine levels, except VEGF in 
      ARMD. In DRP samples of patients with diffuse diabetic macula edema (DME) higher 
      VEGF-A and MCP-1 levels were found than in patients with focal DME. Ischemic DRP 
      had higher VEGF levels than non-ischemic DRP. All measured cytokines were 
      significantly higher in central retinal vein occlusion (CRVO) than in branch 
      retinal vein occlusion (BRVO). CONCLUSIONS: Differences in intravitreal cytokine 
      levels in DRP, RVO and ARMD could be demonstrated. The knowledge of depicted 
      specific characteristic dysregulation of cytokines could allow more targeted 
      future therapies.
FAU - Pfister, M
AU  - Pfister M
AD  - Universitatsaugenklinik, Goethe Universitat, Theodor Stern Kai 7, 60590, 
      Frankfurt am Main, Deutschland. marcel.pfister@kgu.de
FAU - Koch, F H
AU  - Koch FH
FAU - Cinatl, J
AU  - Cinatl J
FAU - Rothweiler, F
AU  - Rothweiler F
FAU - Schubert, R
AU  - Schubert R
FAU - Singh, P
AU  - Singh P
FAU - Ackermann, H
AU  - Ackermann H
FAU - Koss, M J
AU  - Koss MJ
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Zytokinbestimmung aus Glaskorperproben bei retinalen Gefasserkrankungen.
PL  - Germany
TA  - Ophthalmologe
JT  - Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
JID - 9206148
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-6)
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - IM
MH  - Aged
MH  - Biomarkers/analysis
MH  - Chemokine CCL2/*analysis
MH  - Cytokines/analysis
MH  - Female
MH  - Germany/epidemiology
MH  - Humans
MH  - Interleukin-6/*analysis
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Reproducibility of Results
MH  - Retinal Diseases/diagnosis/*epidemiology/*metabolism
MH  - Retinal Vessels/*chemistry
MH  - Risk Factors
MH  - Sensitivity and Specificity
MH  - Vascular Endothelial Growth Factor A/*analysis
MH  - Vitreous Body/*chemistry
EDAT- 2012/12/12 06:00
MHDA- 2014/03/13 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2014/03/13 06:00 [medline]
AID - 10.1007/s00347-012-2719-4 [doi]
PST - ppublish
SO  - Ophthalmologe. 2013 Aug;110(8):746-54. doi: 10.1007/s00347-012-2719-4.