PMID- 23224557
OWN - NLM
STAT- MEDLINE
DCOM- 20121217
LR  - 20230425
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 338
IP  - 6112
DP  - 2012 Dec 7
TI  - Sexually dimorphic BDNF signaling directs sensory innervation of the mammary 
      gland.
PG  - 1357-60
LID - 10.1126/science.1228258 [doi]
AB  - How neural circuits associated with sexually dimorphic organs are differentially 
      assembled during development is unclear. Here, we report a sexually dimorphic 
      pattern of mouse mammary gland sensory innervation and the mechanism of its 
      formation. Brain-derived neurotrophic factor (BDNF), emanating from mammary 
      mesenchyme and signaling through its receptor TrkB on sensory axons, is required 
      for establishing mammary gland sensory innervation of both sexes at early 
      developmental stages. Subsequently, in males, androgens promote mammary 
      mesenchymal expression of a truncated form of TrkB, which prevents BDNF-TrkB 
      signaling in sensory axons and leads to a rapid loss of mammary gland innervation 
      independent of neuronal apoptosis. Thus, sex hormone regulation of a neurotrophic 
      factor signal directs sexually dimorphic axonal growth and maintenance, resulting 
      in generation of a sex-specific neural circuit.
FAU - Liu, Yin
AU  - Liu Y
AD  - The Solomon H. Snyder Department of Neuroscience, Howard Hughes Medical 
      Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, 
      USA.
FAU - Rutlin, Michael
AU  - Rutlin M
FAU - Huang, Siyi
AU  - Huang S
FAU - Barrick, Colleen A
AU  - Barrick CA
FAU - Wang, Fan
AU  - Wang F
FAU - Jones, Kevin R
AU  - Jones KR
FAU - Tessarollo, Lino
AU  - Tessarollo L
FAU - Ginty, David D
AU  - Ginty DD
LA  - eng
GR  - P30 NS050274/NS/NINDS NIH HHS/United States
GR  - R01 NS034814/NS/NINDS NIH HHS/United States
GR  - DE019440/DE/NIDCR NIH HHS/United States
GR  - R01 DE019440/DE/NIDCR NIH HHS/United States
GR  - EY014998/EY/NEI NIH HHS/United States
GR  - NS34814/NS/NINDS NIH HHS/United States
GR  - HHMI/Howard Hughes Medical Institute/United States
GR  - R37 NS034814/NS/NINDS NIH HHS/United States
GR  - R01 EY014998/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Androgens)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Androgens/metabolism
MH  - Animals
MH  - Axons/*physiology
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Female
MH  - Male
MH  - Mammary Glands, Animal/*embryology/*innervation
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Receptor, trkB/genetics/metabolism
MH  - *Sex Characteristics
MH  - Signal Transduction
PMC - PMC3826154
MID - NIHMS525700
OID - NLM: HHMIMS525700
EDAT- 2012/12/12 06:00
MHDA- 2012/12/18 06:00
PMCR- 2013/11/13
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2012/12/18 06:00 [medline]
PHST- 2013/11/13 00:00 [pmc-release]
AID - 338/6112/1357 [pii]
AID - 10.1126/science.1228258 [doi]
PST - ppublish
SO  - Science. 2012 Dec 7;338(6112):1357-60. doi: 10.1126/science.1228258.