PMID- 23224597
OWN - NLM
STAT- MEDLINE
DCOM- 20130722
LR  - 20211021
IS  - 1860-1499 (Electronic)
IS  - 1860-1499 (Linking)
VI  - 45
IP  - 4
DP  - 2012 Dec
TI  - Production and degradation of extracellular matrix in reversible glomerular 
      lesions in rat model of habu snake venom-induced glomerulonephritis.
PG  - 190-8
LID - 10.1007/s00795-011-0559-y [doi]
AB  - We investigated the mechanism of development and repair process of glomerular 
      injury in a rat model of habu snake (Trimeresurus flavoviridis) venom 
      (HSV)-induced glomerulonephritis. Glomerulonephritis was induced in rats by 
      intravenously injecting HSV at 3 mg/kg. Renal tissue was isolated and subjected 
      to immunohistochemical analysis for expression levels of type IV collagen, heat 
      shock protein 47 (HSP47), transforming growth factor-beta (TGF-beta), and matrix 
      metalloproteinase-3 (MMP-3), as well as its transcription factor Ets-1. 
      Expression levels of HSP47, TGF-beta, and type IV collagen began to increase in the 
      mesangial area starting from day 14 and peaked on day 21, followed by a gradual 
      decrease. Expression levels of MMP-3 and Ets-1 started to increase coinciding 
      with peak production of mesangial matrix on day 21, peaking on day 35, followed 
      by gradual decrease. Expression of MMP-3 and Ets-1 persisted until day 63, 
      whereas that of HSP47 and type IV collagen returned to baseline level at this 
      time point. Time-course changes of extracellular matrix (ECM) accumulation in 
      glomeruli in the HSV-induced glomerulonephritis model were correlated with those 
      of factors involved in both ECM production and degradation systems. Continued 
      expression of factors in the degradation system seems particularly important for 
      the repair process. These findings might lead to new therapies that prevent and 
      repair glomerular injury.
FAU - Kawazu, Tayo
AU  - Kawazu T
AD  - Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 
      Sakamoto, Nagasaki 852-8501, Japan.
FAU - Nishino, Tomoya
AU  - Nishino T
FAU - Obata, Yoko
AU  - Obata Y
FAU - Furusu, Akira
AU  - Furusu A
FAU - Miyazaki, Masanobu
AU  - Miyazaki M
FAU - Abe, Katsushige
AU  - Abe K
FAU - Koji, Takehiko
AU  - Koji T
FAU - Kohno, Shigeru
AU  - Kohno S
LA  - eng
PT  - Journal Article
DEP - 20121207
PL  - Japan
TA  - Med Mol Morphol
JT  - Medical molecular morphology
JID - 101239023
RN  - 0 (Collagen Type IV)
RN  - 0 (Crotalid Venoms)
RN  - 0 (Ets1 protein, rat)
RN  - 0 (HSP47 Heat-Shock Proteins)
RN  - 0 (Proto-Oncogene Protein c-ets-1)
RN  - 0 (Serpinh1 protein, rat)
RN  - 0 (Transforming Growth Factor beta)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Animals
MH  - Collagen Type IV/metabolism
MH  - Crotalid Venoms/*toxicity
MH  - Disease Models, Animal
MH  - Extracellular Matrix/*metabolism/pathology
MH  - Glomerulonephritis/chemically induced/*metabolism/*pathology
MH  - HSP47 Heat-Shock Proteins/metabolism
MH  - Male
MH  - Matrix Metalloproteinase 3/metabolism
MH  - Proto-Oncogene Protein c-ets-1/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Transforming Growth Factor beta/metabolism
MH  - *Trimeresurus
EDAT- 2012/12/12 06:00
MHDA- 2013/07/23 06:00
CRDT- 2012/12/11 06:00
PHST- 2011/01/11 00:00 [received]
PHST- 2011/07/28 00:00 [accepted]
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/07/23 06:00 [medline]
AID - 10.1007/s00795-011-0559-y [doi]
PST - ppublish
SO  - Med Mol Morphol. 2012 Dec;45(4):190-8. doi: 10.1007/s00795-011-0559-y. Epub 2012 
      Dec 7.