PMID- 23224755
OWN - NLM
STAT- MEDLINE
DCOM- 20140407
LR  - 20211021
IS  - 1573-742X (Electronic)
IS  - 0929-5305 (Linking)
VI  - 36
IP  - 3
DP  - 2013 Oct
TI  - Lowering homocysteine levels with folic acid and B-vitamins do not reduce early 
      atherosclerosis, but could interfere with cognitive decline and Alzheimer's 
      disease.
PG  - 258-62
LID - 10.1007/s11239-012-0856-x [doi]
AB  - Inheired or acquired hyperhomocysteinemia (HHcy) is associated with several 
      impairments, as certain tumors, deep venous thrombosis, tube neural defects, 
      osteoporosis, early atherosclerosis and vascular acute events (IMA, stroke, PVD), 
      mild cognitive impairments till Alzheimer's disease (AD). But, vascular and 
      neuronal derangements are the most frequent HHcy-manifestations. As far as early 
      atherosclerosis, some clinical trials demonstrated that folates and B6-12 
      vitamins supplementation is unable to reduce atherosclerotic lesions and 
      cardiovascular events, even if it lowers HHcy levels. Thus, for atherosclerosis 
      and its acute events (IMA, stroke, PVD) HHcy acts as a powerful biomarker rather 
      than a risk factor. For that, the supplementation with folates and B vitamins to 
      lower atherosclerotic lesions-events in hyperhomocysteinemic patients is not 
      recommended. On the contrary, several clinical investigations demonstrated that 
      folates and vitamins administration is able to reduce Hcy serum levels and 
      antagonize some mechanisms favouring neurodegenerative impairments, as mild 
      cognitive impairment, AD and dementia. Thus, contrarily to the atherosclerotic 
      manifestations in hyperhomocysteinemic patients, preventive treatment with 
      folates and B6-12 vitamins reduces Hcy concentration and could prevent or delay 
      cognitive decline and AD.
FAU - Cacciapuoti, Federico
AU  - Cacciapuoti F
AD  - Department of Internal Medicine and Geriatry, S.U.N., Naples, Italy, 
      fulvio.cacciapuoti@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - J Thromb Thrombolysis
JT  - Journal of thrombosis and thrombolysis
JID - 9502018
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 12001-76-2 (Vitamin B Complex)
RN  - 935E97BOY8 (Folic Acid)
SB  - IM
MH  - *Alzheimer Disease/blood/drug therapy
MH  - *Atherosclerosis/blood/drug therapy
MH  - Cognition/*drug effects
MH  - Folic Acid/*therapeutic use
MH  - Homocysteine/*blood
MH  - Humans
MH  - Hyperhomocysteinemia/blood/drug therapy
MH  - Vitamin B Complex/*therapeutic use
EDAT- 2012/12/12 06:00
MHDA- 2014/04/08 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2014/04/08 06:00 [medline]
AID - 10.1007/s11239-012-0856-x [doi]
PST - ppublish
SO  - J Thromb Thrombolysis. 2013 Oct;36(3):258-62. doi: 10.1007/s11239-012-0856-x.