PMID- 23224876
OWN - NLM
STAT- MEDLINE
DCOM- 20130314
LR  - 20161109
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 961
DP  - 2013
TI  - Transcriptional regulation of ncx1 gene in the brain.
PG  - 137-45
LID - 10.1007/978-1-4614-4756-6_12 [doi]
AB  - The ubiquitous sodium-calcium exchanger isoform 1 (NCX1) is a -bidirectional 
      transporter that plays a relevant role under physiological and pathophysiological 
      conditions including brain ischemia by regulating intraneuronal Ca(2+) and Na(+) 
      homeostasis. Although changes in ncx1 protein and transcript expression have been 
      detected during stroke, its transcriptional regulation is still largely 
      unexplored. Here, we reviewed our recent findings on several transcription 
      factors including cAMP response element-binding protein (CREB), nuclear factor 
      kappa B (NF-kappaB), and hypoxia-inducible factor-1 (HIF-1) in the control of the 
      ncx1 gene expression in neuronal cells.
FAU - Valsecchi, Valeria
AU  - Valsecchi V
AD  - Department of Neuroscience, Federico II University of Naples, Naples, Italy.
FAU - Pignataro, Giuseppe
AU  - Pignataro G
FAU - Sirabella, Rossana
AU  - Sirabella R
FAU - Matrone, Carmela
AU  - Matrone C
FAU - Boscia, Francesca
AU  - Boscia F
FAU - Scorziello, Antonella
AU  - Scorziello A
FAU - Sisalli, Maria Jose
AU  - Sisalli MJ
FAU - Esposito, Elga
AU  - Esposito E
FAU - Zambrano, Nicola
AU  - Zambrano N
FAU - Cataldi, Mauro
AU  - Cataldi M
FAU - Di Renzo, Gianfranco
AU  - Di Renzo G
FAU - Annunziato, Lucio
AU  - Annunziato L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 0 (CREB1 protein, human)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - 0 (NF-kappa B)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Sodium-Calcium Exchanger)
RN  - 0 (sodium-calcium exchanger 1)
RN  - 9NEZ333N27 (Sodium)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Brain
MH  - Brain Ischemia/*metabolism/pathology
MH  - Calcium/metabolism
MH  - Cyclic AMP Response Element-Binding Protein/metabolism
MH  - *Gene Expression Regulation
MH  - Humans
MH  - Hypoxia-Inducible Factor 1/metabolism
MH  - NF-kappa B/metabolism
MH  - Nerve Tissue Proteins/*metabolism
MH  - Neurons/metabolism/pathology
MH  - Sodium/metabolism
MH  - Sodium-Calcium Exchanger/*biosynthesis
MH  - Stroke/*metabolism/pathology
MH  - *Transcription, Genetic
EDAT- 2012/12/12 06:00
MHDA- 2013/03/15 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/03/15 06:00 [medline]
AID - 10.1007/978-1-4614-4756-6_12 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2013;961:137-45. doi: 10.1007/978-1-4614-4756-6_12.