PMID- 23225225
OWN - NLM
STAT- MEDLINE
DCOM- 20130827
LR  - 20211008
IS  - 1097-4644 (Electronic)
IS  - 0730-2312 (Linking)
VI  - 114
IP  - 5
DP  - 2013 May
TI  - HIFs, angiogenesis, and cancer.
PG  - 967-74
LID - 10.1002/jcb.24438 [doi]
AB  - Tumor hypoxia was first described in the 1950s by radiation oncologists as a 
      frequent cause of failure to radiotherapy in solid tumors. Today, it is evident 
      that tumor hypoxia is a common feature of many cancers and the master regulator 
      of hypoxia, hypoxia-inducible factor-1 (HIF-1), regulates multiple aspects of 
      tumorigenesis, including angiogenesis, proliferation, metabolism, metastasis, 
      differentiation, and response to radiation therapy. Although the tumor hypoxia 
      response mechanism leads to a multitude of downstream effects, it is angiogenesis 
      that is most crucial and also most susceptible to molecular manipulation. The 
      delineation of molecular mechanisms of angiogenesis has revealed a critical role 
      for HIF-1 in the regulation of angiogenic growth factors. In this article, we 
      review what has been described about HIF-1: its structure, its regulation, and 
      its implication for cancer therapy and we focus on its role in angiogenesis and 
      cancer.
CI  - Copyright (c) 2012 Wiley Periodicals, Inc.
FAU - Yang, Yongzhi
AU  - Yang Y
AD  - Student Teams Research Management Unit, Second Military Medical University, 
      Xiangyin Road, Shanghai 200433, P.R. China.
FAU - Sun, Mingjuan
AU  - Sun M
FAU - Wang, Lianghua
AU  - Wang L
FAU - Jiao, Binghua
AU  - Jiao B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - J Cell Biochem
JT  - Journal of cellular biochemistry
JID - 8205768
RN  - 0 (Hypoxia-Inducible Factor 1)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Hypoxia-Inducible Factor 1/chemistry/genetics/*metabolism
MH  - Models, Biological
MH  - Neoplasms/*blood supply/*metabolism/pathology
MH  - Neovascularization, Pathologic/*metabolism
MH  - Signal Transduction
EDAT- 2012/12/12 06:00
MHDA- 2013/08/28 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/09/02 00:00 [received]
PHST- 2012/10/23 00:00 [accepted]
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/08/28 06:00 [medline]
AID - 10.1002/jcb.24438 [doi]
PST - ppublish
SO  - J Cell Biochem. 2013 May;114(5):967-74. doi: 10.1002/jcb.24438.