PMID- 23226029
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121212
LR  - 20220408
IS  - 1178-7066 (Print)
IS  - 1178-7066 (Electronic)
IS  - 1178-7066 (Linking)
VI  - 1
DP  - 2008
TI  - Association study of a brain-derived neurotrophic-factor polymorphism and 
      short-term antidepressant response in major depressive disorders.
PG  - 1-6
AB  - Major depressive disorder (MDD) is one of the most common mental disorders 
      worldwide. Single nucleotide polymorphisms (SNPs) can be used in clinical 
      association studies to determine the contribution of genes to drug efficacy. A 
      common SNP in the brain-derived neurotrophic factor (BDNF) gene, a methionine 
      (Met) substitution for valine (Val) at codon 66 (Val66Met), is a candidate SNP 
      for influencing antidepressant treatment outcome. In this study, our goal was to 
      determine the relationship between the Val66Met polymorphism in the BDNF gene and 
      the rapid antidepressant response to venlafaxine in a Taiwanese population with 
      MDD. Overall, the BDNF Val66Met polymorphism was found not to be associated with 
      short-term venlafaxine treatment outcome. However, the BDNF Val66Met polymorphism 
      showed a trend to be associated with rapid venlafaxine treatment response in 
      female patients. Future research with independent replication in large sample 
      sizes is needed to confirm the role of the BDNF Val66Met polymorphism identified 
      in this study.
FAU - Lin, Eugene
AU  - Lin E
AD  - Vita Genomics, Inc., Wugu Shiang, Taipei, Taiwan; ; These authors contributed 
      equally to this work.
FAU - Chen, Po See
AU  - Chen PS
FAU - Huang, Lung-Cheng
AU  - Huang LC
FAU - Hsu, Sen-Yen
AU  - Hsu SY
LA  - eng
PT  - Journal Article
DEP - 20081021
PL  - New Zealand
TA  - Pharmgenomics Pers Med
JT  - Pharmacogenomics and personalized medicine
JID - 101514107
PMC - PMC3513194
OTO - NOTNLM
OT  - antidepressant response
OT  - brain-derived neurotrophic factor
OT  - major depressive disorder
OT  - serotonin and norepinephrine reuptake inhibitor
OT  - single nucleotide polymorphisms
EDAT- 2008/01/01 00:00
MHDA- 2008/01/01 00:01
PMCR- 2008/10/21
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2008/01/01 00:00 [pubmed]
PHST- 2008/01/01 00:01 [medline]
PHST- 2008/10/21 00:00 [pmc-release]
AID - pgpm_1_1 [pii]
AID - 10.2147/pgpm.s4116 [doi]
PST - ppublish
SO  - Pharmgenomics Pers Med. 2008;1:1-6. doi: 10.2147/pgpm.s4116. Epub 2008 Oct 21.