PMID- 23226034
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121212
LR  - 20211021
IS  - 1178-7066 (Print)
IS  - 1178-7066 (Electronic)
IS  - 1178-7066 (Linking)
VI  - 2
DP  - 2009
TI  - Influence of socioeconomic lifestyle factors and genetic polymorphism on type 2 
      diabetes occurrences among Tunisian Arab and Berber groups of Djerba Island.
PG  - 49-57
AB  - Type 2 diabetes mellitus (T2DM) is characterized by three major metabolic 
      abnormalities: impaired insulin-stimulated glucose uptake in muscle and adipose 
      tissues, alterations in glucose-stimulated insulin secretion, and increased 
      hepatic glucose production. Both genetic and environmental factors contribute to 
      its development. The insulin gene (INS), insulin receptor gene (INSR), and 
      insulin receptor substrate 1 gene (IRS1), identified by polymerase chain reaction 
      and digestion with selected restriction enzymes PstI, NsiI, and BstnI, have been 
      proposed as T2DM candidate genes. To determine the contribution of genetic and 
      environmental factors on the occurrence of T2DM, we examined the frequency of 
      T2DM among two ethnically diverse populations, Arabs and Berbers, who have shared 
      the same environment, the island of Djerba, for thousands of years. Both 
      populations have a high prevalence of obesity,T2DM, and a high consanguinity 
      rate. A total of 162 T2DM men and women were matched to 110 healthy male and 
      female controls. Results showed that the NsiI polymorphism in INSR and BstnI 
      polymorphism of IRS1 were significantly associated with T2DM only among the 
      Berber group. The PstI polymorphism in INS, was not associated with T2DM in 
      either group. Sedentary lifestyles, lower physical activity, and lower 
      educational levels were associated with T2DM among the Berber group. These 
      findings suggest that the insulin receptor gene and lifestyle factors in 
      combination may contribute to the occurrence of T2DM in the Berber portion of 
      this island population.
FAU - Ouederni, Thouraya Baroudi
AU  - Ouederni TB
AD  - Laboratory of Genetics, Immunology and Human Pathology, Faculty of Sciences of 
      Tunis, Tunis, Tunisia;
FAU - Fadiel, Ahmed
AU  - Fadiel A
FAU - Stambouli, Nejla
AU  - Stambouli N
FAU - Scalize, Trudy J
AU  - Scalize TJ
FAU - Ben Maiz, Hedi
AU  - Ben Maiz H
FAU - Abid, Hafaona Kammoun
AU  - Abid HK
FAU - Bouhaha, Rim
AU  - Bouhaha R
FAU - Sanchez-Corona, Jose
AU  - Sanchez-Corona J
FAU - Hamza, Adel
AU  - Hamza A
FAU - Benammar-Elgaaied, Amel
AU  - Benammar-Elgaaied A
LA  - eng
PT  - Journal Article
DEP - 20090821
PL  - New Zealand
TA  - Pharmgenomics Pers Med
JT  - Pharmacogenomics and personalized medicine
JID - 101514107
PMC - PMC3513201
OTO - NOTNLM
OT  - Arabs
OT  - Berbers
OT  - Djerba Island
OT  - insulin
OT  - insulin receptor
OT  - insulin receptor substrate-1
OT  - lifestyle
OT  - polymorphism
EDAT- 2009/01/01 00:00
MHDA- 2009/01/01 00:01
PMCR- 2009/08/21
CRDT- 2012/12/11 06:00
PHST- 2009/08/20 00:00 [received]
PHST- 2012/12/11 06:00 [entrez]
PHST- 2009/01/01 00:00 [pubmed]
PHST- 2009/01/01 00:01 [medline]
PHST- 2009/08/21 00:00 [pmc-release]
AID - pgpm-2-049 [pii]
AID - 10.2147/pgpm.s5850 [doi]
PST - ppublish
SO  - Pharmgenomics Pers Med. 2009;2:49-57. doi: 10.2147/pgpm.s5850. Epub 2009 Aug 21.