PMID- 23226789
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 4
IP  - 4
DP  - 2012 Oct
TI  - The plasticity and potential of leukemia cell lines to differentiate into 
      dendritic cells.
PG  - 595-600
AB  - Dendritic cells (DCs) are potent antigen-presenting cells that orchestrate the 
      innate and adaptive immune systems to induce immunity. DCs are significant in 
      maintaining immune tolerance towards self-antigens, organ transplantation and 
      allergic responses. DCs are powerful adjuvants for eliciting T-cell immunity and 
      are therefore considered primary targets for inducing immune responses in the 
      prevention and treatment of infectious diseases and cancer. DCs have been 
      increasingly applied in the immunotherapy of cancer worldwide during the last 
      decade; however, a number of the highly specialized biological characteristics of 
      DCs remain to be elucidated. Previous studies of human DCs have been constrained 
      by certain difficulties, therefore the majority of studies have been carried out 
      using in vitro model systems. Suitable cell lines with dendritic-like properties 
      may provide valuable tools for the study of DC physiology and pathology. In the 
      current review, various human DC line differentiation models are discussed. 
      Certain cell lines provide valuable tools for studying the specific aspects of DC 
      biology, despite variations in cell biological and immunological features when 
      compared with primary DCs.
FAU - Guo, Qingwei
AU  - Guo Q
AD  - Qilu Children's Hospital of Shandong University, Jinan 250022;
FAU - Zhang, Leling
AU  - Zhang L
FAU - Li, Fu
AU  - Li F
FAU - Jiang, Guosheng
AU  - Jiang G
LA  - eng
PT  - Journal Article
DEP - 20120725
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC3506589
EDAT- 2012/12/12 06:00
MHDA- 2012/12/12 06:01
PMCR- 2012/07/25
CRDT- 2012/12/11 06:00
PHST- 2012/04/11 00:00 [received]
PHST- 2012/07/10 00:00 [accepted]
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2012/12/12 06:01 [medline]
PHST- 2012/07/25 00:00 [pmc-release]
AID - ol-04-04-0595 [pii]
AID - 10.3892/ol.2012.821 [doi]
PST - ppublish
SO  - Oncol Lett. 2012 Oct;4(4):595-600. doi: 10.3892/ol.2012.821. Epub 2012 Jul 25.