PMID- 23226849
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121212
LR  - 20211021
IS  - 0019-5545 (Print)
IS  - 1998-3794 (Electronic)
IS  - 0019-5545 (Linking)
VI  - 54
IP  - 3
DP  - 2012 Jul
TI  - Atypical antipsychotics usage in long-term follow-up of first episode 
      schizophrenia.
PG  - 248-52
LID - 10.4103/0019-5545.102425 [doi]
AB  - BACKGROUND: It is not clear if the role of antipsychotics in long-term clinical 
      and functional recovery from schizophrenia is correlated. The pattern of use is a 
      major aspect of pharmacotherapy in long-term follow-ups of schizophrenia. The aim 
      of this study was to examine patterns of antipsychotic usage in patients with 
      longstanding psychosis and their relationship to social outcomes. MATERIALS AND 
      METHODS: We conducted a cross-sectional study on a cohort from a long-term 
      outcome study. Participants were 116 first episode schizophrenia patients from 
      Mumbai, India, who had more than 80% compliance, as reported by relatives. 
      Patients were assessed on antipsychotic medication use and on clinical and 
      functional parameters. RESULTS: There was a high compliance rate (72%). Most 
      patients (77%) used atypical antipsychotics; only 10 (8.6%) patients were taking 
      typical antipsychotics. There were no among-drug differences in the percentage of 
      patients meeting the recommended dose: Clozapine (200-500 mg), Riseperidone 
      (4.0-6.0 mg), Olanzapine (10-20 mg), Quetiapine (400-800 mg), Aripiprazole (15-30 
      mg), Ziprasidone (120-160 mg); an equivalent dosage of Chlorpromazine (300-600 
      mg) did not differ amongst any atypical antipsychotic subgroup. Also, we did not 
      find any significant differences in recovery on Clinical Global Impression 
      Severity scale (CGIS), Quality of Life (QOL), or Global Assessment of Functioning 
      (GAF) between groups of antipsychotic drugs. CONCLUSION: This study shows that 
      most patients suffering from schizophrenia, in a long-term follow-up, use 
      prescribed atypical antipsychotics within the recommended limits. Also, the 
      chlorpromazine equivalence dosages do not differ across antipsychotic 
      medications. The outcomes on clinical and functional parameters are also similar 
      across all second-generation antipsychotics.
FAU - Shrivastava, Amresh
AU  - Shrivastava A
AD  - Department of Psychiatry, Elgin Early Intervention Program for Psychosis, The 
      University of Western Ontario, Ontario, Canada, and Mental Health Resource 
      Foundation, Mumbai, Maharashtra, India.
FAU - Johnston, Megan
AU  - Johnston M
FAU - Terpstra, Kristen
AU  - Terpstra K
FAU - Stitt, Larry
AU  - Stitt L
FAU - Shah, Nilesh
AU  - Shah N
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Psychiatry
JT  - Indian journal of psychiatry
JID - 0013255
PMC - PMC3512362
OTO - NOTNLM
OT  - Antipsychotics
OT  - long-term outcome
OT  - prescribing
OT  - schizophrenia
COIS- Conflict of Interest: None declared
EDAT- 2012/12/12 06:00
MHDA- 2012/12/12 06:01
PMCR- 2012/07/01
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2012/12/12 06:01 [medline]
PHST- 2012/07/01 00:00 [pmc-release]
AID - IJPsy-54-248 [pii]
AID - 10.4103/0019-5545.102425 [doi]
PST - ppublish
SO  - Indian J Psychiatry. 2012 Jul;54(3):248-52. doi: 10.4103/0019-5545.102425.