PMID- 23227796
OWN - NLM
STAT- MEDLINE
DCOM- 20130514
LR  - 20121211
IS  - 1793-6853 (Electronic)
IS  - 0192-415X (Linking)
VI  - 40
IP  - 6
DP  - 2012
TI  - Aqueous extract of Mosla chinensis inhibits mast cell-mediated allergic 
      inflammation.
PG  - 1257-70
LID - 10.1142/S0192415X12500930 [doi]
AB  - Allergic inflammatory diseases such as food allergy, asthma, sinusitis, and 
      atopic dermatitis are increasing worldwide. In this study, we investigated the 
      effects of aqueous extract of Mosla chinensis Max. (AMC) on mast cell-mediated 
      allergic inflammation and studied the possible mechanism of this action. AMC 
      inhibited compound 48/80-induced systemic and immunoglobulin E (IgE)-mediated 
      local anaphylaxis. AMC reduced intracellular calcium levels and downstream 
      histamine release from rat peritoneal mast cells activated by compound 48/80 or 
      IgE. In addition, AMC decreased gene expression and secretion of proinflammatory 
      cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-8 in 
      human mast cells. The inhibitory effect of AMC on cytokine expression was nuclear 
      factor (NF)-kappaB dependent. Our results indicate that AMC inhibits mast 
      cell-mediated allergic inflammatory reaction by suppressing histamine release and 
      expression of proinflammatory cytokines and the involvement of calcium and NF-kappaB 
      in these effects. AMC might be a possible therapeutic candidate for allergic 
      inflammatory disorders.
FAU - Kim, Hui-Hun
AU  - Kim HH
AD  - CMRI, Department of Pharmacology, School of Medicine, Kyungpook National 
      University, Daegu 700-422, Republic of Korea.
FAU - Yoo, Jin-Su
AU  - Yoo JS
FAU - Shin, Tae-Yong
AU  - Shin TY
FAU - Kim, Sang-Hyun
AU  - Kim SH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Singapore
TA  - Am J Chin Med
JT  - The American journal of Chinese medicine
JID - 7901431
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Animals
MH  - Blotting, Western
MH  - Cytokines/metabolism
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Histamine Release/drug effects
MH  - Hypersensitivity/immunology/metabolism/*prevention & control
MH  - Inflammation/immunology/*prevention & control
MH  - Inflammation Mediators/metabolism
MH  - Lamiaceae/*chemistry
MH  - Male
MH  - Mast Cells/*drug effects/metabolism
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Plant Extracts/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2012/12/12 06:00
MHDA- 2013/05/15 06:00
CRDT- 2012/12/12 06:00
PHST- 2012/12/12 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/05/15 06:00 [medline]
AID - 10.1142/S0192415X12500930 [doi]
PST - ppublish
SO  - Am J Chin Med. 2012;40(6):1257-70. doi: 10.1142/S0192415X12500930.