PMID- 23228281
OWN - NLM
STAT- MEDLINE
DCOM- 20140717
LR  - 20151119
IS  - 1873-4898 (Electronic)
IS  - 1477-5131 (Linking)
VI  - 9
IP  - 6 Pt A
DP  - 2013 Dec
TI  - Epidermal growth factor and monocyte chemotactic peptide-1: potential biomarkers 
      of urinary tract obstruction in children with hydronephrosis.
PG  - 838-45
LID - S1477-5131(12)00285-9 [pii]
LID - 10.1016/j.jpurol.2012.11.011 [doi]
AB  - OBJECTIVE: Hydronephrosis is diagnosed in 0.5% of all newborns, and ureteropelvic 
      junction obstruction (UPJO) is a common cause. The aim of this study was to test 
      whether specific urinary cytokines can be used as UPJO biomarkers in children 
      with hydronephrosis. MATERIALS AND METHODS: Twenty-eight children referred for 
      pyeloplasty due to UPJO and 13 controls were included in this prospective study. 
      Kidney function was assessed and urine samples collected pre-, peri-, and 
      post-operatively. Urine levels of epidermal growth factor (EGF), monocyte 
      chemotactic peptide-1 (MCP-1), macrophage inflammatory protein-1alpha (MIP-1alpha), 
      interferon-gamma-inducible protein-10 (IP-10), and RANTES were measured 
      simultaneously by using a bead-based multiplex sandwich immunoassay. RESULTS: In 
      hydronephrotic children, preoperative urine levels were significantly increased 
      for EGF (median 7.4 [1.2-60.2] vs. median 4.0 [1.2-13.8] ng/mg creatinine) and 
      MCP-1 (median 136.9 [47.7-545.5] vs. median 80.1 [28.8-149.9] pg/mg creatinine) 
      compared to those of controls. Urine levels of EGF and MCP-1 were identical to 
      controls at the postoperative 1-year follow-up exam. CONCLUSION: Urine levels of 
      EGF and MCP-1 were preoperatively increased and postoperatively normalized. This 
      study demonstrates that urine-excreted kidney cytokines may be potential 
      biomarkers of obstruction in children with hydronephrosis.
CI  - Copyright (c) 2012 Journal of Pediatric Urology Company. Published by Elsevier Ltd. 
      All rights reserved.
FAU - Madsen, Mia Gebauer
AU  - Madsen MG
AD  - Department of Urology, Pediatric Section, Aarhus University Hospital, 
      Brendstrupgaardsvej 100, 8200 Aarhus N, Denmark; The Water and Salt Research 
      Center, Department of Clinical Medicine, Aarhus University Hospital, Aarhus, 
      Denmark. Electronic address: miagebauermadsen@ki.au.dk.
FAU - Norregaard, Rikke
AU  - Norregaard R
FAU - Palmfeldt, Johan
AU  - Palmfeldt J
FAU - Olsen, Lars Henning
AU  - Olsen LH
FAU - Frokiaer, Jorgen
AU  - Frokiaer J
FAU - Jorgensen, Troels Munch
AU  - Jorgensen TM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121208
PL  - England
TA  - J Pediatr Urol
JT  - Journal of pediatric urology
JID - 101233150
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (CCL3 protein, human)
RN  - 0 (CCL5 protein, human)
RN  - 0 (CXCL10 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL3)
RN  - 0 (Chemokine CCL5)
RN  - 0 (Chemokine CXCL10)
RN  - 62229-50-9 (Epidermal Growth Factor)
SB  - IM
MH  - Adolescent
MH  - Biomarkers/urine
MH  - Chemokine CCL2/*urine
MH  - Chemokine CCL3/urine
MH  - Chemokine CCL5/urine
MH  - Chemokine CXCL10/urine
MH  - Child
MH  - Child, Preschool
MH  - Epidermal Growth Factor/*urine
MH  - Female
MH  - Humans
MH  - Hydronephrosis/*complications/surgery
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Preoperative Care
MH  - Prospective Studies
MH  - Ureteral Obstruction/diagnosis/*etiology/*urine
OTO - NOTNLM
OT  - Epidermal growth factor
OT  - Hydronephrosis
OT  - Monocyte chemotactic peptide-1
OT  - Ureteropelvic junction obstruction
OT  - Urinary biomarker
EDAT- 2012/12/12 06:00
MHDA- 2014/07/18 06:00
CRDT- 2012/12/12 06:00
PHST- 2012/06/22 00:00 [received]
PHST- 2012/11/13 00:00 [accepted]
PHST- 2012/12/12 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2014/07/18 06:00 [medline]
AID - S1477-5131(12)00285-9 [pii]
AID - 10.1016/j.jpurol.2012.11.011 [doi]
PST - ppublish
SO  - J Pediatr Urol. 2013 Dec;9(6 Pt A):838-45. doi: 10.1016/j.jpurol.2012.11.011. 
      Epub 2012 Dec 8.