PMID- 23233196
OWN - NLM
STAT- MEDLINE
DCOM- 20130617
LR  - 20211021
IS  - 1613-2246 (Electronic)
IS  - 0021-5155 (Linking)
VI  - 57
IP  - 2
DP  - 2013 Mar
TI  - Recovery from deepening of the upper eyelid sulcus after switching from 
      bimatoprost to latanoprost.
PG  - 179-84
LID - 10.1007/s10384-012-0219-3 [doi]
AB  - PURPOSE: Although useful for reducing intraocular pressure (IOP), bimatoprost 
      (BIM) can cause deepening of the upper eyelid sulcus (DUES), one of the symptoms 
      of prostaglandin-associated periorbitopathy (PAP). We investigated recovery from 
      BIM-induced DUES after switching treatment to latanoprost (LAT). DESIGN: 
      Prospective, observer-masked, open-label study. METHODS: Twenty-five Japanese 
      patients suffering from primary open-angle glaucoma treated with LAT in both eyes 
      for longer than 6 months and requiring further IOP reduction were prospectively 
      enrolled in the study. During the first 6 months after the switch to BIM, 15 of 
      the 25 patients (60 %) developed DUES. Among these patients, 13 were switched 
      back to LAT and re-examined for DUES at 2-month intervals for an additional 
      6 months. RESULTS: Two months after the switch back to LAT, for 11 of the 13 
      patients (85 %) the DUES symptoms had either decreased or disappeared, and this 
      was maintained for at least 6 months. During this time, 6 of 8 patients (75 %) 
      subjectively positive for DUES self-reported a decrease in DUES. CONCLUSIONS: 
      Although DUES is a frequent side effect of treatment with BIM, switching to LAT 
      may reverse the condition for most patients.
FAU - Sakata, Rei
AU  - Sakata R
AD  - Department of Ophthalmology, Tokyo Metropolitan Geriatric Hospital, 35-2 
      Sakaecho, Itabashi, Tokyo, Japan. reisakata-tky@umin.ac.jp
FAU - Shirato, Shiroaki
AU  - Shirato S
FAU - Miyata, Kazunori
AU  - Miyata K
FAU - Aihara, Makoto
AU  - Aihara M
LA  - eng
PT  - Journal Article
DEP - 20121213
PL  - Japan
TA  - Jpn J Ophthalmol
JT  - Japanese journal of ophthalmology
JID - 0044652
RN  - 0 (Amides)
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Prostaglandins F, Synthetic)
RN  - 4208238832 (Cloprostenol)
RN  - 6Z5B6HVF6O (Latanoprost)
RN  - QXS94885MZ (Bimatoprost)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Amides/*adverse effects
MH  - Antihypertensive Agents/*adverse effects/*therapeutic use
MH  - Bimatoprost
MH  - Cloprostenol/adverse effects/*analogs & derivatives
MH  - Drug Substitution
MH  - Eyelid Diseases/chemically induced/*physiopathology
MH  - Eyelids/drug effects/*physiopathology
MH  - Female
MH  - Glaucoma, Open-Angle/*drug therapy/physiopathology
MH  - Humans
MH  - Intraocular Pressure/drug effects
MH  - Latanoprost
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Prostaglandins F, Synthetic/*therapeutic use
MH  - Recovery of Function
EDAT- 2012/12/13 06:00
MHDA- 2013/06/19 06:00
CRDT- 2012/12/13 06:00
PHST- 2012/06/26 00:00 [received]
PHST- 2012/10/15 00:00 [accepted]
PHST- 2012/12/13 06:00 [entrez]
PHST- 2012/12/13 06:00 [pubmed]
PHST- 2013/06/19 06:00 [medline]
AID - 10.1007/s10384-012-0219-3 [doi]
PST - ppublish
SO  - Jpn J Ophthalmol. 2013 Mar;57(2):179-84. doi: 10.1007/s10384-012-0219-3. Epub 
      2012 Dec 13.