PMID- 23234021
OWN - NLM
STAT- MEDLINE
DCOM- 20130118
LR  - 20121213
IS  - 0324-0959 (Print)
IS  - 0324-0959 (Linking)
VI  - 51
IP  - 4
DP  - 2012
TI  - [Treatment of cervical carcinoma IB2 stage].
PG  - 18-23
AB  - OBJECTIVE: To establish the overall and disease-free survival (OS and DFS) in 
      patients IB2 stage FIGO with primary surgical treatment or operated on after 
      preoperative RT. MATERIAL AND METHODS: Between 2003-2011 98 patients (FIGO IB2 
      stage) were operated on. 83 patients were submitted to primary surgery (radical 
      hysterectomy class III with pelvic lymph node dissection--group 1 and 11 were 
      operated on after preoperative RT - 30 Gy - group 2. All operated patients were 
      submitted to adjuvant RT - 52 Gy. Four patients were operated on after NCT 
      (neoadjuvant chemotherapy). All patients were followed between 2 and 96 
      months--median period of 45 months. RESULTS: The acturial OS and DFS for all 
      patients were estimated as 73.5% and 75.6% respectively. The OS and DFS for group 
      1 were estimated as 73.5% and 74.7% respectively. The OS and DFS for group 2 were 
      estimated as 72.8% and 82%, respectively. CONCLUSION: Stage IB2 cervical cancer 
      is related to worse prognosis in comparison to IB1 FIGO stage, because of the 
      higher incidence of distant metastases. Preoperative RT doesn't change the 
      oncological outcomes. There is no statistical difference between group 1 and 
      group 2 in terms of survival. Is important to perform paraaortic lymph node 
      dissection and concurrent radiochemotherapy in these patients.
FAU - Kornovski, Y
AU  - Kornovski Y
FAU - Ismail, E
AU  - Ismail E
FAU - Kaneva, M
AU  - Kaneva M
LA  - bul
PT  - English Abstract
PT  - Journal Article
PL  - Bulgaria
TA  - Akush Ginekol (Sofiia)
JT  - Akusherstvo i ginekologiia
JID - 0370455
SB  - IM
MH  - Adult
MH  - Carcinoma/diagnosis/pathology/*radiotherapy/*surgery
MH  - Cervix Uteri/pathology/*radiation effects/*surgery
MH  - Chemoradiotherapy
MH  - Disease-Free Survival
MH  - Female
MH  - Humans
MH  - Hysterectomy
MH  - Lymph Node Excision
MH  - Middle Aged
MH  - Neoplasm Grading
MH  - Prognosis
MH  - Uterine Cervical Neoplasms/diagnosis/pathology/*radiotherapy/*surgery
EDAT- 2012/12/14 06:00
MHDA- 2013/01/19 06:00
CRDT- 2012/12/14 06:00
PHST- 2012/12/14 06:00 [entrez]
PHST- 2012/12/14 06:00 [pubmed]
PHST- 2013/01/19 06:00 [medline]
PST - ppublish
SO  - Akush Ginekol (Sofiia). 2012;51(4):18-23.