PMID- 23234022
OWN - NLM
STAT- MEDLINE
DCOM- 20130118
LR  - 20121213
IS  - 0324-0959 (Print)
IS  - 0324-0959 (Linking)
VI  - 51
IP  - 4
DP  - 2012
TI  - [Oncological outcomes of combined therapy in patients with cervical carcinoma 
      FIGO stage IIB].
PG  - 24-9
AB  - OBJECTIVE: To establish the overall and disease-free survival and the role of 
      surgery as well as in cervical cancer stage IIB (FIGO) patients submitted to 
      combined radiotherapy and surgery. MATERIAL AND METHODS: Between 2003-2011 86 
      patients with cervical cancer stage IIB had been operated on. Five patients were 
      operated on after neoajuvant chemotherapy. Thirty one women (group 3) had primary 
      pelvic surgery (radical hysterectomy class III and lymphonodulectomy) and 
      adjuvant RT until 52 Gy and 50 women were operated on after preoperative RT (30 
      Gy) and were submitted to adjuvant RT until 52 Gy (group 4). RESULTS: After 
      median follow of 45 months the acturial overall and disease-free survival (OS and 
      DFS) were estimated as 75.6% and 77.9% respectively for all patients staged IIB 
      (FIGO). In group 3 the incidence of local relapses and distant metastases was 
      9.7% and 12.9%, respectively and in group 4--local and distant recurrences were 
      6% and 14%, respectively. The acturial OS and DFS for group 3 were 80.6% and 
      77.5%, respectively and for group 4--76% and 80% (NS). CONCLUSION: Combinated 
      treatment (RT and pelvic surgery) produce reliable local control of the disease 
      (cervical cancer IIB stage) but is ineffective for metastases outside the small 
      pelvis which is the cause of worse survival of patients with cervical cancer 
      stage IIB (FIGO). Preoperative RT (group 4) doesn't change the OS and DFS 
      significantly. The main indication for surgery in patients with cervical cancer 
      stage IIB is the surgical staging (pelvic and paraaortic lymph node dissection) 
      which enables the appropriate individual treatment planning.
FAU - Kornovski, Y
AU  - Kornovski Y
FAU - Ismail, E
AU  - Ismail E
FAU - Kaneva, M
AU  - Kaneva M
LA  - bul
PT  - English Abstract
PT  - Journal Article
PL  - Bulgaria
TA  - Akush Ginekol (Sofiia)
JT  - Akusherstvo i ginekologiia
JID - 0370455
SB  - IM
MH  - Adult
MH  - Carcinoma/pathology/*radiotherapy/*surgery
MH  - Cervix Uteri/pathology/*radiation effects/*surgery
MH  - Combined Modality Therapy
MH  - Disease-Free Survival
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Lymph Nodes/pathology/radiation effects/surgery
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Pelvis/pathology/radiation effects/surgery
MH  - Radiotherapy, Adjuvant
MH  - Treatment Outcome
MH  - Uterine Cervical Neoplasms/pathology/*radiotherapy/*surgery
EDAT- 2012/12/14 06:00
MHDA- 2013/01/19 06:00
CRDT- 2012/12/14 06:00
PHST- 2012/12/14 06:00 [entrez]
PHST- 2012/12/14 06:00 [pubmed]
PHST- 2013/01/19 06:00 [medline]
PST - ppublish
SO  - Akush Ginekol (Sofiia). 2012;51(4):24-9.