PMID- 23236551
OWN - NLM
STAT- MEDLINE
DCOM- 20130722
LR  - 20211021
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 6
IP  - 1
DP  - 2013
TI  - Acute myeloid leukemia with cryptic CBFB-MYH11 type D.
PG  - 110-2
AB  - A 77 year-old female was found with FAB M4Eo acute myeloid leukemia. Although 
      CBFB-MYH11 mRNA was detected in RT-PCR, the conventional cytogenetic analysis 
      failed to reveal inv(16). Fluorescence in situ hybridization (FISH) and the 
      sequence analysis revealed a fusion between the exon 5 of CBFB and the exon 8 of 
      MYH11, resulting in a minor variant fusion product previously reported as type D. 
      In order to detect the cryptic inv(16) type D, both FISH and RT-PCR are required, 
      and furthermore, the primers for the sequence analysis needs to be selected for 
      the proper diagnosis.
FAU - Kobayashi, Takashi
AU  - Kobayashi T
AD  - Department of Hematology and Oncology, Graduate School of Medicine, University of 
      Tokyo Tokyo, Japan.
FAU - Ichikawa, Motoshi
AU  - Ichikawa M
FAU - Kamikubo, Yasuhiko
AU  - Kamikubo Y
FAU - Kurokawa, Mineo
AU  - Kurokawa M
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20121120
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
RN  - 0 (CBFB protein, human)
RN  - 0 (Core Binding Factor beta Subunit)
RN  - 0 (MYH11 protein, human)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - EC 3.6.4.1 (Myosin Heavy Chains)
SB  - IM
MH  - Aged
MH  - Chromosome Inversion
MH  - Core Binding Factor beta Subunit/*genetics
MH  - Cytogenetic Analysis
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Myeloid, Acute/*diagnosis/*genetics
MH  - Myosin Heavy Chains/*genetics
MH  - Oncogene Proteins, Fusion/analysis/*genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction
PMC - PMC3515980
OTO - NOTNLM
OT  - Acute myeloid leukemia
OT  - CBFB-MYH11
OT  - RT-PCR
OT  - fluorescence in situ hybridization
OT  - inversion 16
EDAT- 2012/12/14 06:00
MHDA- 2013/07/23 06:00
PMCR- 2012/11/20
CRDT- 2012/12/14 06:00
PHST- 2012/10/09 00:00 [received]
PHST- 2012/11/03 00:00 [accepted]
PHST- 2012/12/14 06:00 [entrez]
PHST- 2012/12/14 06:00 [pubmed]
PHST- 2013/07/23 06:00 [medline]
PHST- 2012/11/20 00:00 [pmc-release]
PST - ppublish
SO  - Int J Clin Exp Pathol. 2013;6(1):110-2. Epub 2012 Nov 20.