PMID- 2323715
OWN - NLM
STAT- MEDLINE
DCOM- 19900517
LR  - 20061115
IS  - 0016-254X (Print)
IS  - 0016-254X (Linking)
VI  - 81
IP  - 1
DP  - 1990 Jan
TI  - [Intracerebral sites of action of estrogen on the sleep-wakefulness circadian 
      rhythm in female rats].
PG  - 48-67
AB  - Effects of estradiol on the sleep-wakefulness circadian rhythm were studied in 
      ovariectomized female rats under a 12: 12 light-dark schedule. In rats that were 
      subcutaneously injected with 20 micrograms of estradiol benzoate (EB) or that had 
      crystalline EB implanted into the third ventricle (III V), the total time of slow 
      wave sleep (SWS) and paradoxical sleep (PS) in the night time was significantly 
      decreased on the third day after the EB administration. The suppression of PS was 
      more remarkable than that of SWS. Slight increases were observed in the total 
      time of SWS and PS in the day time. These effects of estrogen on the appearance 
      patterns of SWS and PS in the night and day time could be elicited in spayed rats 
      after crystalline EB was implanted into the medial preoptic area (MPO) or the 
      medial amygdala (mAMYG), but the implant into the latter proved less effective. 
      Cholesterol implants into IIIV, MPO or mAMYG produced no change in the 
      sleep-wakefulness circadian pattern. Implantations of crystalline EB into the 
      ventromedial hypothalamic nucleus or the dorsomedial thalamic nucleus were 
      ineffective. These results indicate that MPO is probably the most effective site 
      of estrogen on the sleep-wakefulness circadian rhythm of female rats.
FAU - Matsushima, M
AU  - Matsushima M
AD  - Department of Psychiatry, Saga Medical School.
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Fukuoka Igaku Zasshi
JT  - Fukuoka igaku zasshi = Hukuoka acta medica
JID - 9423321
RN  - 0 (Estrogens)
SB  - IM
MH  - Amygdala/*physiology
MH  - Animals
MH  - Circadian Rhythm/*physiology
MH  - Estrogens/*physiology
MH  - Female
MH  - Preoptic Area/*physiology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Sleep/*physiology
MH  - Wakefulness/*physiology
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
PST - ppublish
SO  - Fukuoka Igaku Zasshi. 1990 Jan;81(1):48-67.