PMID- 23237224
OWN - NLM
STAT- MEDLINE
DCOM- 20140702
LR  - 20211021
IS  - 1000-467X (Print)
IS  - 1944-446X (Electronic)
IS  - 1944-446X (Linking)
VI  - 32
IP  - 7
DP  - 2013 Jul
TI  - Volumetric modulation arc radiotherapy with flattening filter-free beams compared 
      with conventional beams for nasopharyngeal carcinoma: a feasibility study.
PG  - 397-402
LID - 10.5732/cjc.012.10182 [doi]
AB  - There is increasing interest in the clinical use of flattening filter-free (FFF) 
      beams. In this study, we aimed to investigate the dosimetric characteristics of 
      volumetric modulated arc radiotherapy (VMAT) with FFF beams for nasopharyngeal 
      carcinoma (NPC). Ten NPC patients were randomly selected to undergo a RapidArc 
      plan with either FFF beams (RA-FFF) or conventional beams (RA-C). The doses to 
      the planning target volumes (PTVs), organs at risk (OARs), and normal tissues 
      were compared. The technical delivery parameters for RapidArc plans were also 
      assessed to compare the characteristics of FFF and conventional beams. Both 
      techniques delivered adequate doses to PTVs. For PTVs, RA-C delivered lower 
      maximum and mean doses and improved conformity and homogeneity compared with 
      RA-FFF. Both techniques provided similar maximum doses to the optic nerves and 
      lenses. For the brain stem, spinal cord, larynx, parotid glands, oral cavity, and 
      skin, RA-FFF showed significant dose increases compared to RA-C. The dose to 
      normal tissue was lower in RA-FFF. The monitor units (MUs) were (536 +/- 46) MU for 
      RA-FFF and (501 +/-25) MU for RA-C. The treatment duration did not significantly 
      differ between plans. Although both treatment plans could meet clinical needs, 
      RA-C is dosimetrically superior to RA-FFF for NPC radiotherapy.
FAU - Zhuang, Mingzan
AU  - Zhuang M
AD  - Department of Radiation Oncology, Tumor Hospital of Shantou University Medical 
      College, Shantou, Guangdong, People's Republic of China.
FAU - Zhang, Tuodan
AU  - Zhang T
FAU - Chen, Zhijian
AU  - Chen Z
FAU - Lin, Zhixiong
AU  - Lin Z
FAU - Li, Derui
AU  - Li D
FAU - Peng, Xun
AU  - Peng X
FAU - Qiu, Qingchun
AU  - Qiu Q
FAU - Wu, Renhua
AU  - Wu R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121214
PL  - England
TA  - Chin J Cancer
JT  - Chinese journal of cancer
JID - 101498232
SB  - IM
MH  - Adult
MH  - Aged
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nasopharyngeal Neoplasms/pathology/*radiotherapy
MH  - Organs at Risk/*radiation effects
MH  - Radiometry/methods
MH  - Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted/*methods
MH  - Radiotherapy, Intensity-Modulated/*methods
PMC - PMC3845599
EDAT- 2012/12/15 06:00
MHDA- 2014/07/06 06:00
PMCR- 2013/07/01
CRDT- 2012/12/15 06:00
PHST- 2012/12/15 06:00 [entrez]
PHST- 2012/12/15 06:00 [pubmed]
PHST- 2014/07/06 06:00 [medline]
PHST- 2013/07/01 00:00 [pmc-release]
AID - cjc.012.10182 [pii]
AID - cjc-32-07-397 [pii]
AID - 10.5732/cjc.012.10182 [doi]
PST - ppublish
SO  - Chin J Cancer. 2013 Jul;32(7):397-402. doi: 10.5732/cjc.012.10182. Epub 2012 Dec 
      14.