PMID- 23237784
OWN - NLM
STAT- MEDLINE
DCOM- 20130321
LR  - 20201209
IS  - 2213-0276 (Electronic)
IS  - 0755-4982 (Linking)
VI  - 42
IP  - 2
DP  - 2013 Feb
TI  - [Emergent adverse effects of proton pump inhibitors].
PG  - e53-62
LID - S0755-4982(12)00604-5 [pii]
LID - 10.1016/j.lpm.2012.09.016 [doi]
AB  - BACKGROUND: Recent literature reports of potential adverse effects (AEs) of 
      proton pump inhibitors (PPIs), especially during long-term treatments. PURPOSE: 
      To present a literature review of major AEs: digestive infections, pneumonia, 
      bone fracture, hypomagnesemia, interstitial nephritis, gastric cancer and 
      neutropenia. DATA SOURCES: The authors used Pubmed; articles in English or 
      French, published between August 2006 and August 2011 were analyzed. STUDY 
      SELECTION: Two reviewers analyzed the references of title and summary to retain 
      mainly observational studies, controlled clinical trials, meta-analyzes, case 
      reports. RESULTS: For digestive infections: observational studies have shown a 
      link moderate to high (OR 1.4 to 8.3) with exposure to PPIs. For pneumonia: some 
      case-control studies reported a modest significative risk (OR 1.2 to 1.6), some 
      not. The risk appears dose dependent and greater in subjects at risk. For 
      fractures: the majority of observational studies report a significative increase 
      in low to moderate risk (OR 1.2 to 3.1), correlated with the dose and duration of 
      treatment. For magnesium deficiency: rare but potentially severe, they are 
      described in case reports. Interstitial nephritis are described in case reports 
      and for different PPIs, suggesting a class effect. For the stomach neoplasm: if 
      three observational studies show an increased cancer risk (OR 1.5 to 2, 3), 
      confounding factors make the causal link uncertain. Neutropenia is reported in a 
      clinical observation, a class effect is suggested. LIMITATIONS: One can regret 
      the absence of controlled clinical trials; indeed the observational studies have 
      the interest to move closer to "real life", but often have methodological bias. 
      CONCLUSION: Although AEs PPIs do not call into question the usefulness of this 
      drug class, they show the need to limit their prescribing to indications for 
      which efficacy has been proven. Moreover, PPIs treatment must be regularly 
      reassessed to avoid exposing patients to unnecessary risks.
CI  - Copyright (c) 2012 Elsevier Masson SAS. All rights reserved.
FAU - Bourne, Cindy
AU  - Bourne C
AD  - Groupement Hospitalier Sud, Hospices Civils de Lyon, Hopital Henry Gabrielle, 
      Departement de Pharmacie Clinique, 69230 St Genis Laval, France.
FAU - Charpiat, Bruno
AU  - Charpiat B
FAU - Charhon, Nicolas
AU  - Charhon N
FAU - Bertin, Camille
AU  - Bertin C
FAU - Gouraud, Aurore
AU  - Gouraud A
FAU - Mouchoux, Christelle
AU  - Mouchoux C
FAU - Skalli, Saadia
AU  - Skalli S
FAU - Janoly-Dumenil, Audrey
AU  - Janoly-Dumenil A
LA  - fre
PT  - Journal Article
PT  - Review
TT  - Effets indesirables emergents des inhibiteurs de la pompe a protons.
DEP - 20121210
PL  - France
TA  - Presse Med
JT  - Presse medicale (Paris, France : 1983)
JID - 8302490
RN  - 0 (Proton Pump Inhibitors)
RN  - Hypomagnesemia primary
SB  - IM
MH  - Algorithms
MH  - Clostridioides difficile/pathogenicity
MH  - Drug-Related Side Effects and Adverse Reactions/*epidemiology
MH  - Enterocolitis, Pseudomembranous/chemically induced/epidemiology/etiology
MH  - Fractures, Bone/chemically induced/epidemiology/etiology
MH  - Humans
MH  - Hypercalciuria/chemically induced/epidemiology/etiology
MH  - Incidence
MH  - Lung Diseases/chemically induced/epidemiology/etiology
MH  - Neoplasms/chemically induced/epidemiology/etiology
MH  - Nephrocalcinosis/chemically induced/epidemiology/etiology
MH  - Proton Pump Inhibitors/*adverse effects
MH  - Renal Tubular Transport, Inborn Errors/chemically induced/epidemiology/etiology
MH  - Risk Factors
EDAT- 2012/12/15 06:00
MHDA- 2013/03/22 06:00
CRDT- 2012/12/15 06:00
PHST- 2012/05/13 00:00 [received]
PHST- 2012/08/08 00:00 [revised]
PHST- 2012/09/04 00:00 [accepted]
PHST- 2012/12/15 06:00 [entrez]
PHST- 2012/12/15 06:00 [pubmed]
PHST- 2013/03/22 06:00 [medline]
AID - S0755-4982(12)00604-5 [pii]
AID - 10.1016/j.lpm.2012.09.016 [doi]
PST - ppublish
SO  - Presse Med. 2013 Feb;42(2):e53-62. doi: 10.1016/j.lpm.2012.09.016. Epub 2012 Dec 
      10.