PMID- 23239606
OWN - NLM
STAT- MEDLINE
DCOM- 20131029
LR  - 20131121
IS  - 1552-4965 (Electronic)
IS  - 1549-3296 (Linking)
VI  - 101
IP  - 7
DP  - 2013 Jul
TI  - Magnesium incorporation into beta-TCP reduced its in vivo resorption by decreasing 
      parathormone production.
PG  - 1986-93
LID - 10.1002/jbm.a.34502 [doi]
AB  - Beta-tricalcium phosphate (beta-TCP), one of the most widely used bioresorbable 
      materials for bone therapy, can be doped with magnesium ions, generating beta-TCMP. 
      The objectives of this work were to evaluate, on a murine dental alveolus 
      grafting model, the biocompatibility of beta-TCP and beta-TMCP granules by 
      histomorphometric analysis, as well as the impact on plasmatic levels of receptor 
      activator of nuclear factor kappaB ligand (RANK-L), osteoprotegerin (OPG), 
      osteocalcin, osteopontin, and parathormone (PTH) during bone repair, using 
      Luminex multiplexing technology. After grafting for 42 days, beta-TCP grafted group 
      presented higher bioresorption and induced more newly formed bone than beta-TCMP (p 
      < 0.05). beta-TCP grafting also induced higher plasmatic levels of RANK-L, compared 
      to beta-TCMP and control (blood clot) groups at 21st day (p < 0.05). PTH, which 
      remained at low levels in control group, presented a time-dependent increase in 
      grafted groups, attaining significantly higher levels with beta-TCP by the 42nd day 
      (p < 0.05). RANK-L/OPG ratio increased on beta-TCP group and attained a peak on the 
      21st day. In conclusion, beta-TCP granules were more bioresorbable and osteogenic 
      than beta-TCMP granules, and the resorption of both materials might have been 
      affected by osteoclastogenesis modulated by changes in the plasmatic levels of 
      PTH and RANK-L.
CI  - Copyright (c) 2012 Wiley Periodicals, Inc.
FAU - Yassuda, Debora H
AU  - Yassuda DH
AD  - Department of Metallurgy and Materials, Federal University of Rio de 
      Janeiro/COPPE, Rio de Janeiro, RJ, Brazil.
FAU - Costa, Neusa F M
AU  - Costa NF
FAU - Fernandes, Gustavo O
AU  - Fernandes GO
FAU - Alves, Gutemberg G
AU  - Alves GG
FAU - Granjeiro, Jose M
AU  - Granjeiro JM
FAU - Soares, Gloria de A
AU  - Soares Gde A
LA  - eng
PT  - Journal Article
DEP - 20121213
PL  - United States
TA  - J Biomed Mater Res A
JT  - Journal of biomedical materials research. Part A
JID - 101234237
RN  - 0 (Biocompatible Materials)
RN  - 0 (Calcium Phosphates)
RN  - 0 (Osteoprotegerin)
RN  - 0 (Parathyroid Hormone)
RN  - 0 (Powders)
RN  - 0 (RANK Ligand)
RN  - 0 (beta-tricalcium phosphate)
RN  - 104982-03-8 (Osteocalcin)
RN  - 106441-73-0 (Osteopontin)
RN  - I38ZP9992A (Magnesium)
SB  - IM
MH  - Animals
MH  - Biocompatible Materials/*chemistry
MH  - Calcium Phosphates/*chemistry/*pharmacology
MH  - Crystallization
MH  - Immunoassay
MH  - Magnesium/*chemistry/*pharmacology
MH  - Materials Testing
MH  - Osteocalcin/blood
MH  - Osteogenesis
MH  - Osteopontin/blood
MH  - Osteoprotegerin/blood
MH  - Parathyroid Hormone/*biosynthesis
MH  - Powders
MH  - RANK Ligand/blood
MH  - Rats
MH  - Rats, Wistar
MH  - Tooth Socket
MH  - X-Ray Diffraction
EDAT- 2012/12/15 06:00
MHDA- 2013/10/30 06:00
CRDT- 2012/12/15 06:00
PHST- 2012/07/17 00:00 [received]
PHST- 2012/10/05 00:00 [revised]
PHST- 2012/10/11 00:00 [accepted]
PHST- 2012/12/15 06:00 [entrez]
PHST- 2012/12/15 06:00 [pubmed]
PHST- 2013/10/30 06:00 [medline]
AID - 10.1002/jbm.a.34502 [doi]
PST - ppublish
SO  - J Biomed Mater Res A. 2013 Jul;101(7):1986-93. doi: 10.1002/jbm.a.34502. Epub 
      2012 Dec 13.