PMID- 23239932
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121217
LR  - 20211021
IS  - 1179-5549 (Electronic)
IS  - 1179-5549 (Linking)
VI  - 6
DP  - 2012
TI  - Clinical Significance of ALK-1 Gene Abnormalities in Diffuse Large Cell Lymphoma.
PG  - 395-405
LID - 10.4137/CMO.S9920 [doi]
AB  - OBJECTIVES: To detect relative frequency of anaplastic lymphoma kinase (ALK-1) 
      gene abnormality in diffuse large cell lymphoma (DLCL) using fluorescence in situ 
      hybridization (FISH), and correlate its presence with clinicopathological 
      features which may be useful for choice of therapy and predict survival in newly 
      diagnosed cases. PATIENTS AND METHODS: A prospective study was done between March 
      2004 and October 2009. Fifty patients newly diagnosed with DLCL were enrolled 
      into the study. Immunophenotyping was done and detection of ALK-1 gene 
      abnormalities were carried out by immunohistochemically (IHC) and FISH. Patients 
      that proved to be ALK-1 positive were treated with standard cyclophosphamide 
      -hydroxy-daunorubicin- oncovin-prednisone (CHOP) protocol. RESULTS: All ALK +ve 
      patients achieved complete remission (CR) vs. 93.5% CR and 6.5% partial remission 
      (PR) for ALK -ve patients respectively. Disease free survival (DFS) at 24 months 
      was 81.8% in the CHOP-14 group (ALK-1(-)) vs. 100% for the CHOP-21 group 
      (ALK-1(+)). Overall survival (OS) at 30 months was 80.4% in the CHOP-14 group vs. 
      100% for the CHOP-21 group.
FAU - Korashy, L
AU  - Korashy L
AD  - Department of Clinical Oncology, Faculty of Medicine, Tanta University.
FAU - El-Zawahry, H
AU  - El-Zawahry H
FAU - Abdou, S
AU  - Abdou S
FAU - Shahin, D
AU  - Shahin D
FAU - Sherif, F
AU  - Sherif F
FAU - Farrag, W
AU  - Farrag W
FAU - Abdel-Khalik, O
AU  - Abdel-Khalik O
FAU - Salem, H
AU  - Salem H
FAU - El-Sebaaie, A
AU  - El-Sebaaie A
LA  - eng
PT  - Journal Article
DEP - 20121126
PL  - United States
TA  - Clin Med Insights Oncol
JT  - Clinical Medicine Insights. Oncology
JID - 101525771
PMC - PMC3516130
OTO - NOTNLM
OT  - ALCL
OT  - ALK-1
OT  - FISH
OT  - IHC
EDAT- 2012/12/15 06:00
MHDA- 2012/12/15 06:01
PMCR- 2012/11/26
CRDT- 2012/12/15 06:00
PHST- 2012/12/15 06:00 [entrez]
PHST- 2012/12/15 06:00 [pubmed]
PHST- 2012/12/15 06:01 [medline]
PHST- 2012/11/26 00:00 [pmc-release]
AID - cmo-6-2012-395 [pii]
AID - 10.4137/CMO.S9920 [doi]
PST - ppublish
SO  - Clin Med Insights Oncol. 2012;6:395-405. doi: 10.4137/CMO.S9920. Epub 2012 Nov 
      26.