PMID- 23240009
OWN - NLM
STAT- MEDLINE
DCOM- 20130530
LR  - 20221207
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 12
DP  - 2012
TI  - Associations of BDNF genotype and promoter methylation with acute and long-term 
      stroke outcomes in an East Asian cohort.
PG  - e51280
LID - 10.1371/journal.pone.0051280 [doi]
LID - e51280
AB  - BACKGROUND: Brain derived neurotrophic factor (BDNF) has been shown to play an 
      important role in poststroke recovery. BDNF secretion is influenced by genetic 
      and epigenetic profiles. This study aimed to investigate whether BDNF val66met 
      polymorphism and promoter methylation status were associated with outcomes at two 
      weeks and one year after stroke. METHODS AND FINDINGS: A total of 286 patients 
      were evaluated at the time of admission and two weeks after stroke, and 222 (78%) 
      were followed one year later in order to evaluate consequences of stroke at both 
      acute and chronic stages. Stroke outcomes were dichotomised into good and poor by 
      the modified Rankin Scale. Stroke severity (National Institutes of Health Stroke 
      Scale), physical disability (Barthel Index), and cognitive function (Mini-Mental 
      State Examination) were measured. Associations of BDNF genotype and methylation 
      status on stroke outcomes and assessment scale scores were investigated using 
      logistic regression, repeated measures ANOVA and partial correlation tests. BDNF 
      val66met polymorphism was independently associated with poor outcome at 2 weeks 
      and at 1 year, and with worsening physical disability and cognitive function over 
      that period. Higher BDNF promoter methylation status was independently associated 
      with worse outcomes at 1 year, and with the worsening of physical disability and 
      cognitive function. No significant genotype-methylation interactions were found. 
      CONCLUSIONS: A role for BDNF in poststroke recovery was supported, and clinical 
      utility of BDNF genetic and epigenetic profile as prognostic biomarkers and a 
      target for drug development was suggested.
FAU - Kim, Jae-Min
AU  - Kim JM
AD  - Department of Psychiatry, Chonnam National University Medical School, Gwangju, 
      Korea. jmkim@chonnam.ac.kr
FAU - Stewart, Robert
AU  - Stewart R
FAU - Park, Man-Seok
AU  - Park MS
FAU - Kang, Hee-Ju
AU  - Kang HJ
FAU - Kim, Sung-Wan
AU  - Kim SW
FAU - Shin, Il-Seon
AU  - Shin IS
FAU - Kim, Hye-Ran
AU  - Kim HR
FAU - Shin, Myung-Geun
AU  - Shin MG
FAU - Cho, Ki-Hyun
AU  - Cho KH
FAU - Yoon, Jin-Sang
AU  - Yoon JS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121211
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Asian People/genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - DNA Methylation/genetics
MH  - Female
MH  - *Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - *Promoter Regions, Genetic
MH  - Severity of Illness Index
MH  - *Stroke/genetics/physiopathology
PMC - PMC3519835
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2012/12/15 06:00
MHDA- 2013/06/01 06:00
PMCR- 2012/12/11
CRDT- 2012/12/15 06:00
PHST- 2012/08/03 00:00 [received]
PHST- 2012/10/31 00:00 [accepted]
PHST- 2012/12/15 06:00 [entrez]
PHST- 2012/12/15 06:00 [pubmed]
PHST- 2013/06/01 06:00 [medline]
PHST- 2012/12/11 00:00 [pmc-release]
AID - PONE-D-12-23229 [pii]
AID - 10.1371/journal.pone.0051280 [doi]
PST - ppublish
SO  - PLoS One. 2012;7(12):e51280. doi: 10.1371/journal.pone.0051280. Epub 2012 Dec 11.