PMID- 23242788
OWN - NLM
STAT- MEDLINE
DCOM- 20130815
LR  - 20211021
IS  - 1573-6903 (Electronic)
IS  - 0364-3190 (Linking)
VI  - 38
IP  - 3
DP  - 2013 Mar
TI  - The protective effects of Achyranthes bidentata polypeptides on rat sciatic nerve 
      crush injury causes modulation of neurotrophic factors.
PG  - 538-46
LID - 10.1007/s11064-012-0946-3 [doi]
AB  - Pharmacological treatment is a therapeutic approach to improving nerve 
      regeneration and functional recovery after peripheral nerve crush injury. The 
      objective of the present study was to investigate the effects of the polypeptides 
      isolated from Achyranthes bidentata Blume (abbreviated as ABPP) on rat sciatic 
      crush injury and to test the possible involvement of neurotrophic factors. After 
      surgical crush injury, rats received daily intraperitoneal injection of 0.2 ml 
      saline containing 2 mg ABPP, 1 mug nerve growth factor (NGF) or no additive. The 
      results from walking track analysis, electrophysiological assessment and 
      histological evaluation indicated that the repair outcomes by ABPP treatment were 
      close to those by NGF treatment, but better than those by treatment with saline 
      alone. The quantitative real-time RT-PCR was used to monitor the mRNA expression 
      of growth associated protein in the crush nerves and the mRNA expression of NGF, 
      brain-derived neurotrophic factor (BDNF), ciliary neurotrophic factor (CNTF), 
      tyrosine kinase (Trk)A and TrkB in the dorsal root ganglia (DRGs) at L4-L6. The 
      mRNA expression of these genes in the crush nerve sample and DRGs sample was 
      higher after treatment with ABPP or NGF than after treatment with saline alone. 
      Our findings suggest that ABPP might protect peripheral nerve against crush 
      injury through stimulating release of neurotrophic factors and the other 
      cytokines.
FAU - Wang, Yaxian
AU  - Wang Y
AD  - Jiangsu Key Laboratory of Neuroregeneration, Nantong University, 19 Qixiu Road, 
      Nantong, 226001, Jiangsu, China.
FAU - Shen, Weixing
AU  - Shen W
FAU - Yang, Lingyan
AU  - Yang L
FAU - Zhao, Hualong
AU  - Zhao H
FAU - Gu, Wei
AU  - Gu W
FAU - Yuan, Ying
AU  - Yuan Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121215
PL  - United States
TA  - Neurochem Res
JT  - Neurochemical research
JID - 7613461
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (GAP-43 Protein)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Peptides)
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Achyranthes/*chemistry
MH  - Animals
MH  - Drugs, Chinese Herbal/*therapeutic use
MH  - GAP-43 Protein/biosynthesis
MH  - Nerve Crush
MH  - Nerve Growth Factors/*metabolism/therapeutic use
MH  - Peptides/*therapeutic use
MH  - Peripheral Nerve Injuries/*drug therapy
MH  - Plant Extracts/*therapeutic use
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sciatic Nerve/injuries/physiology
MH  - Sciatic Neuropathy/*drug therapy
EDAT- 2012/12/18 06:00
MHDA- 2013/08/16 06:00
CRDT- 2012/12/18 06:00
PHST- 2012/04/16 00:00 [received]
PHST- 2012/11/29 00:00 [accepted]
PHST- 2012/09/08 00:00 [revised]
PHST- 2012/12/18 06:00 [entrez]
PHST- 2012/12/18 06:00 [pubmed]
PHST- 2013/08/16 06:00 [medline]
AID - 10.1007/s11064-012-0946-3 [doi]
PST - ppublish
SO  - Neurochem Res. 2013 Mar;38(3):538-46. doi: 10.1007/s11064-012-0946-3. Epub 2012 
      Dec 15.