PMID- 23243280
OWN - NLM
STAT- MEDLINE
DCOM- 20130405
LR  - 20220318
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Linking)
VI  - 121
IP  - 7
DP  - 2013 Feb 14
TI  - Inhibitory KIR/HLA incompatibility between sexual partners confers protection 
      against HIV-1 transmission.
PG  - 1157-64
LID - 10.1182/blood-2012-09-455352 [doi]
AB  - Killer immunoglobulin-like receptors (KIRs) regulate natural killer (NK) cells in 
      a human leukocyte antigen (HLA)-dependent manner. KIR/HLA mismatched 
      hematopoietic stem cell transplants induce alloreactive NK cells, which prevent 
      leukemia relapse. Certain KIR/HLA combinations protect against HIV-1 infection, 
      but the effect of KIR/HLA mismatches between sexual partners has never been 
      investigated. In this study, we analyzed the effect of allogeneic KIR/HLA 
      combinations on HIV-1 transmission in a West African population of 
      HIV-1-discordant and concordant couples. HIV-1-discordant couples were 
      characterized by recipient partners with homozygous KIR2DL2, and by a mismatched 
      recipient partner KIR2DL1/HLA-C2 with index partner HLA-C1/C1 combination 
      expected to allow licensed missing self NK cell killing of index partners' cells. 
      HIV-1-concordant couples on the other hand were characterized by KIR2DL3 
      homozygous recipient partners with HLA-C1/C2 bearing index partners, resulting in 
      a matched KIR/HLA combination expected to inhibit NK cell killing. In vitro 
      cocultures of healthy donor-derived NK cells and HIV-1 patient-derived CD4(+) T 
      cells confirmed the involvement of these allogeneic KIR/HLA combinations in NK 
      cell-mediated CD4(+) T-cell killing. Our data suggest that KIR/HLA 
      incompatibility between sexual partners confers protection against HIV-1 
      transmission and that this may be due to alloreactive NK cell killing of the 
      HIV-1-infected partner's cells.
FAU - Jennes, Wim
AU  - Jennes W
AD  - Laboratory of Immunology, Department of Biomedical Sciences, Institute of 
      Tropical Medicine, Antwerp, Belgium. wjennes@itg.be
FAU - Verheyden, Sonja
AU  - Verheyden S
FAU - Mertens, Julie W
AU  - Mertens JW
FAU - Camara, Makhtar
AU  - Camara M
FAU - Seydi, Moussa
AU  - Seydi M
FAU - Dieye, Tandakha N
AU  - Dieye TN
FAU - Mboup, Souleymane
AU  - Mboup S
FAU - Demanet, Christian
AU  - Demanet C
FAU - Kestens, Luc
AU  - Kestens L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121213
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (Isoantigens)
RN  - 0 (KIR2DL2 protein, human)
RN  - 0 (Receptors, KIR)
RN  - 0 (Receptors, KIR2DL2)
SB  - IM
CIN - Blood. 2013 Sep 12;122(11):1983-4. PMID: 24030258
CIN - Blood. 2013 Sep 12;122(11):1984-5. PMID: 24030259
MH  - Adult
MH  - Africa, Western
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - Coculture Techniques
MH  - Cytotoxicity, Immunologic
MH  - Female
MH  - HIV Infections/genetics/*immunology/prevention & control/*transmission
MH  - HIV Seronegativity/genetics/immunology
MH  - *HIV-1
MH  - HLA Antigens/genetics/*immunology
MH  - HLA-C Antigens/genetics/immunology
MH  - Humans
MH  - Immunity, Innate
MH  - Isoantigens/genetics/immunology
MH  - Killer Cells, Natural/immunology
MH  - Male
MH  - Middle Aged
MH  - Receptors, KIR/genetics/*immunology
MH  - Receptors, KIR2DL2/genetics/immunology
MH  - Sexual Partners
EDAT- 2012/12/18 06:00
MHDA- 2013/04/06 06:00
CRDT- 2012/12/18 06:00
PHST- 2012/12/18 06:00 [entrez]
PHST- 2012/12/18 06:00 [pubmed]
PHST- 2013/04/06 06:00 [medline]
AID - S0006-4971(20)42114-7 [pii]
AID - 10.1182/blood-2012-09-455352 [doi]
PST - ppublish
SO  - Blood. 2013 Feb 14;121(7):1157-64. doi: 10.1182/blood-2012-09-455352. Epub 2012 
      Dec 13.