PMID- 23244085
OWN - NLM
STAT- MEDLINE
DCOM- 20130604
LR  - 20190606
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Linking)
VI  - 13
IP  - 10
DP  - 2012
TI  - Fusion between TMPRSS2 and ETS family members (ERG, ETV1, ETV4) in prostate 
      cancers from northern China.
PG  - 4935-8
AB  - In this study we evaluated the frequency of fusion between TMPRSS2 and ETS family 
      members (ERG, ETV1, ETV4) in prostate cancers in patients from northern China in 
      order to explore differences in fusion rates among regions in northern and 
      southern China, other parts of Asia, Europe, and North America. We examined 100 
      prostate cancer patients, diagnosed by means of prostate biopsy; fluorescence in 
      situ hybridization (FISH) was used to detect the expression of TMPRSS2, ERG, ETV1 
      and ETV4 in cancer tissue. Differences in gene fusion rates among different 
      ethnics groups were also analyzed. Of the 100 prostate cancer patients, 55 (55%) 
      had the fusion gene. Among the patients with the fusion gene, 46 (83.6%) patients 
      had the TMPRSS2:ERG fusion product, 8 (14.8%) patients had TMPRSS2:ETV1 fusion, 1 
      (1.6%) patient had TMPRSS2:ETV4.
FAU - Wang, Jian-Jiang
AU  - Wang JJ
AD  - Department of Urology, Beijing Tongren Hospital, Capital Medical University, 
      Beijing, China.
FAU - Liu, Yue-Xin
AU  - Liu YX
FAU - Wang, Wei
AU  - Wang W
FAU - Yan, Wei
AU  - Yan W
FAU - Zheng, Yu-Peng
AU  - Zheng YP
FAU - Qiao, Lu-Dong
AU  - Qiao LD
FAU - Liu, Dan
AU  - Liu D
FAU - Chen, Shan
AU  - Chen S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (TMPRSS2-ERG fusion protein, human)
RN  - 0 (TMPRSS2-ETV1 fusion protein, human)
RN  - 0 (TMPRSS2-ETV4 fusion protein, human)
SB  - IM
MH  - Biomarkers, Tumor/*genetics
MH  - China
MH  - *Gene Fusion
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Oncogene Proteins, Fusion/*genetics
MH  - Prognosis
MH  - Prostatic Neoplasms/diagnosis/*genetics/surgery
EDAT- 2012/12/19 06:00
MHDA- 2013/06/05 06:00
CRDT- 2012/12/19 06:00
PHST- 2012/12/19 06:00 [entrez]
PHST- 2012/12/19 06:00 [pubmed]
PHST- 2013/06/05 06:00 [medline]
AID - 10.7314/apjcp.2012.13.10.4935 [doi]
PST - ppublish
SO  - Asian Pac J Cancer Prev. 2012;13(10):4935-8. doi: 10.7314/apjcp.2012.13.10.4935.