PMID- 23245768
OWN - NLM
STAT- MEDLINE
DCOM- 20130820
LR  - 20211021
IS  - 1879-3061 (Electronic)
IS  - 1043-2760 (Print)
IS  - 1043-2760 (Linking)
VI  - 24
IP  - 2
DP  - 2013 Feb
TI  - Prolyl carboxypeptidase and its inhibitors in metabolism.
PG  - 61-7
LID - S1043-2760(12)00201-9 [pii]
LID - 10.1016/j.tem.2012.11.001 [doi]
AB  - Proopiomelanocortin (POMC)-expressing neurons in the hypothalamus integrate a 
      variety of central and peripheral metabolic inputs, and regulate energy 
      homeostasis by controlling energy expenditure and food intake. To accomplish 
      this, a precise balance of production and degradation of alpha-melanocyte-stimulating 
      hormone (alpha-MSH), an anorexigenic neuropeptide and product of the POMC gene, in 
      the hypothalamus, is crucial. Prolyl carboxypeptidase (PRCP) is a key enzyme that 
      degrades alpha-MSH to an inactive form unable to inhibit food intake. Because it 
      represents a new therapeutic target for the treatment of metabolic disorders, 
      such as obesity and diabetes, efforts have been made to generate potent, 
      brain-penetrant PRCP inhibitors. Here, we discuss the role of PRCP on energy 
      metabolism and the development of PRCP inhibitors.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Jeong, Jin Kwon
AU  - Jeong JK
AD  - Program in Integrative Cell Signaling and Neurobiology of Metabolism, Yale 
      University School of Medicine, New Haven, CT 06520, USA.
FAU - Diano, Sabrina
AU  - Diano S
LA  - eng
GR  - R01 DK084065/DK/NIDDK NIH HHS/United States
GR  - DK 084065/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20121212
PL  - United States
TA  - Trends Endocrinol Metab
JT  - Trends in endocrinology and metabolism: TEM
JID - 9001516
RN  - 0 (Enzyme Inhibitors)
RN  - 66796-54-1 (Pro-Opiomelanocortin)
RN  - EC 3.4.11.- (Aminopeptidases)
RN  - EC 3.4.11.5 (prolyl aminopeptidase)
SB  - IM
MH  - Aminopeptidases/*antagonists & inhibitors/*metabolism
MH  - Eating/drug effects
MH  - Enzyme Inhibitors/pharmacology
MH  - Humans
MH  - Hypothalamus/drug effects/metabolism
MH  - Pro-Opiomelanocortin/metabolism
PMC - PMC3893043
MID - NIHMS429149
EDAT- 2012/12/19 06:00
MHDA- 2013/08/21 06:00
PMCR- 2014/02/01
CRDT- 2012/12/19 06:00
PHST- 2012/09/11 00:00 [received]
PHST- 2012/10/30 00:00 [revised]
PHST- 2012/11/04 00:00 [accepted]
PHST- 2012/12/19 06:00 [entrez]
PHST- 2012/12/19 06:00 [pubmed]
PHST- 2013/08/21 06:00 [medline]
PHST- 2014/02/01 00:00 [pmc-release]
AID - S1043-2760(12)00201-9 [pii]
AID - 10.1016/j.tem.2012.11.001 [doi]
PST - ppublish
SO  - Trends Endocrinol Metab. 2013 Feb;24(2):61-7. doi: 10.1016/j.tem.2012.11.001. 
      Epub 2012 Dec 12.