PMID- 23246615
OWN - NLM
STAT- MEDLINE
DCOM- 20131017
LR  - 20220318
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 239
DP  - 2013 Jun 3
TI  - Interplay between thyroxin, BDNF and GABA in injured neurons.
PG  - 241-52
LID - S0306-4522(12)01187-6 [pii]
LID - 10.1016/j.neuroscience.2012.12.007 [doi]
AB  - Accumulating experimental evidence suggests that groups of neurons in the CNS 
      might react to pathological insults by activating developmental-like programs for 
      survival, regeneration and re-establishment of lost connections. For instance, in 
      cell and animal models it was shown that after trauma mature central neurons 
      become dependent on brain-derived neurotrophic factor (BDNF) trophic support for 
      survival. This event is preceded by a shift of postsynaptic GABAA 
      receptor-mediated responses from hyperpolarization to developmental-like 
      depolarization. These profound functional changes in GABAA receptor-mediated 
      transmission and the requirement of injured neurons for BDNF trophic support are 
      interdependent. Thyroid hormones (THs) play a crucial role in the development of 
      the nervous system, having significant effects on dendritic branching, 
      synaptogenesis and axonal growth to name a few. In the adult nervous system TH 
      thyroxin has been shown to have a neuroprotective effect and to promote 
      regeneration in experimental trauma models. Interestingly, after trauma there is 
      a qualitative change in the regulatory effect of thyroxin on BDNF expression as 
      well as on GABAergic transmission. In this review we provide an overview of the 
      post-traumatic changes in these signaling systems and discuss the potential 
      significance of their interactions for the development of novel therapeutic 
      strategies.
CI  - Copyright (c) 2012 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Shulga, A
AU  - Shulga A
AD  - Department of Neurological Sciences, Institute of Clinical Medicine, Faculty of 
      Medicine, University of Helsinki, Finland. anastasia.shulga@helsinki.fi
FAU - Rivera, C
AU  - Rivera C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20121213
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Animals
MH  - Brain Injuries/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Humans
MH  - Neurons/*metabolism
MH  - Signal Transduction/physiology
MH  - Thyroxine/*metabolism
MH  - gamma-Aminobutyric Acid/*metabolism
EDAT- 2012/12/19 06:00
MHDA- 2013/10/18 06:00
CRDT- 2012/12/19 06:00
PHST- 2012/08/12 00:00 [received]
PHST- 2012/12/04 00:00 [revised]
PHST- 2012/12/05 00:00 [accepted]
PHST- 2012/12/19 06:00 [entrez]
PHST- 2012/12/19 06:00 [pubmed]
PHST- 2013/10/18 06:00 [medline]
AID - S0306-4522(12)01187-6 [pii]
AID - 10.1016/j.neuroscience.2012.12.007 [doi]
PST - ppublish
SO  - Neuroscience. 2013 Jun 3;239:241-52. doi: 10.1016/j.neuroscience.2012.12.007. 
      Epub 2012 Dec 13.