PMID- 23246678
OWN - NLM
STAT- MEDLINE
DCOM- 20130219
LR  - 20181202
IS  - 1090-2163 (Electronic)
IS  - 0008-8749 (Linking)
VI  - 279
IP  - 2
DP  - 2012 Oct
TI  - Over-expressing transporters associated with antigen processing increases 
      antitumor immunity response in prostate cancer.
PG  - 167-73
LID - S0008-8749(12)00188-8 [pii]
LID - 10.1016/j.cellimm.2012.10.004 [doi]
AB  - As we know, prostate cancer down-regulates expression of HLA-1 Antigen Processing 
      Machinery (APM) and has defects in the antigen presentation pathway. In vitro, 
      the prostate cancer cell (PC-3 cells) infected with Lentivirus TAP1 can 
      efficiently over-express TAP1 and Tapasin, and HLA-1 was also up-regulated on the 
      surface of the infected cells. The lentivirus TAP1 infection increased the 
      apoptosis rate of PC-3 cells. In addition, with the co-cluture PC-3 cells and 
      lymphocytes, TAP1 augmented the expression of CD3(+)CD8(+)CD38(+) T cell. Importantly, 
      administration of Lentivirus TAP1 to prostate cancer cells in a xenograft mouse 
      model can prolong survival and increase the CD4(+) T cells, and CD8(+) T cells as 
      well as decrease Foxp3(+) T cells in the tumor microenvironment. In summary, a 
      recombinant lentivirus expressing TAP1 can effectively increase prostate cancer 
      tumor-specific immune response.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Qiu, Tao
AU  - Qiu T
AD  - Department of Urology, Renmin Hospital of Wuhan University, Wuhan, China.
FAU - Wang, Lei
AU  - Wang L
FAU - Liu, Xiu-heng
AU  - Liu XH
FAU - Weng, Xiao-dong
AU  - Weng XD
FAU - Kuang, You-lin
AU  - Kuang YL
FAU - Chen, Zhi-yuan
AU  - Chen ZY
FAU - Chen, Hui
AU  - Chen H
FAU - Zhu, Heng-cheng
AU  - Zhu HC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121029
PL  - Netherlands
TA  - Cell Immunol
JT  - Cellular immunology
JID - 1246405
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B, Member 2)
RN  - 0 (ATP-Binding Cassette Transporters)
RN  - 0 (CD3 Complex)
RN  - 0 (CD8 Antigens)
RN  - 0 (FOXP3 protein, human)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Membrane Transport Proteins)
RN  - 0 (TAP1 protein, human)
RN  - 0 (tapasin)
RN  - EC 3.2.2.6 (ADP-ribosyl Cyclase 1)
SB  - IM
MH  - ADP-ribosyl Cyclase 1/analysis
MH  - ATP Binding Cassette Transporter, Subfamily B, Member 2
MH  - ATP-Binding Cassette Transporters/*metabolism
MH  - Animals
MH  - *Antigen Presentation
MH  - Apoptosis
MH  - CD3 Complex/analysis
MH  - CD8 Antigens/analysis
MH  - Cell Line, Tumor
MH  - Cells, Cultured
MH  - Coculture Techniques
MH  - Forkhead Transcription Factors/biosynthesis
MH  - Histocompatibility Antigens Class I/immunology
MH  - Humans
MH  - Lentivirus
MH  - Male
MH  - Membrane Transport Proteins/*metabolism
MH  - Mice
MH  - Prostatic Neoplasms/*immunology
MH  - T-Lymphocytes/*immunology
MH  - Transplantation, Heterologous
MH  - Tumor Microenvironment
EDAT- 2012/12/19 06:00
MHDA- 2013/02/21 06:00
CRDT- 2012/12/19 06:00
PHST- 2012/05/16 00:00 [received]
PHST- 2012/10/14 00:00 [revised]
PHST- 2012/10/15 00:00 [accepted]
PHST- 2012/12/19 06:00 [entrez]
PHST- 2012/12/19 06:00 [pubmed]
PHST- 2013/02/21 06:00 [medline]
AID - S0008-8749(12)00188-8 [pii]
AID - 10.1016/j.cellimm.2012.10.004 [doi]
PST - ppublish
SO  - Cell Immunol. 2012 Oct;279(2):167-73. doi: 10.1016/j.cellimm.2012.10.004. Epub 
      2012 Oct 29.